ORC4_ORYSJ
ID ORC4_ORYSJ Reviewed; 470 AA.
AC Q5N8Q4; A0A0P0V6N4; B9EYM5; Q7Y0X0;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Origin of replication complex subunit 4 {ECO:0000303|PubMed:15939553};
DE Short=OsORC4 {ECO:0000303|PubMed:15939553};
GN Name=ORC4 {ECO:0000303|PubMed:15939553};
GN OrderedLocusNames=LOC_Os01g49010 {ECO:0000305}, Os01g0683400 {ECO:0000305};
GN ORFNames=OsJ_03032 {ECO:0000312|EMBL:EEE55188.1},
GN P0445E10.9 {ECO:0000312|EMBL:BAD82152.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947 {ECO:0000312|Proteomes:UP000059680};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION BY SUCROSE, TISSUE
RP SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15939553; DOI=10.1016/j.gene.2005.03.047;
RA Mori Y., Yamamoto T., Sakaguchi N., Ishibashi T., Furukawa T., Kadota Y.,
RA Kuchitsu K., Hashimoto J., Kimura S., Sakaguchi K.;
RT "Characterization of the origin recognition complex (ORC) from a higher
RT plant, rice (Oryza sativa L.).";
RL Gene 353:23-30(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [8]
RP REVIEW ON THE CORE DNA REPLICATION MACHINERY.
RX PubMed=17556508; DOI=10.1104/pp.107.101105;
RA Shultz R.W., Tatineni V.M., Hanley-Bowdoin L., Thompson W.F.;
RT "Genome-wide analysis of the core DNA replication machinery in the higher
RT plants Arabidopsis and rice.";
RL Plant Physiol. 144:1697-1714(2007).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC sequences that define origins of replication have not been identified
CC yet. ORC is required to assemble the pre-replication complex necessary
CC to initiate DNA replication. {ECO:0000250|UniProtKB:O43929}.
CC -!- SUBUNIT: Component of the origin recognition complex (ORC) composed of
CC at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a
CC cell-cycle and development dependent manner. It is sequentially
CC assembled at the exit from anaphase of mitosis and disassembled as
CC cells enter S phase. {ECO:0000250|UniProtKB:Q6EWX1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43929}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5N8Q4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5N8Q4-2; Sequence=VSP_057261;
CC -!- TISSUE SPECIFICITY: Expressed in the shoot apical meristem (SAM),
CC leaves, ears and roots (including root tips).
CC {ECO:0000269|PubMed:15939553}.
CC -!- INDUCTION: Reduced expression upon sucrose depletion-mediated cell
CC proliferation arrest, and accumulates after sucrose treatment.
CC {ECO:0000269|PubMed:15939553}.
CC -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000305}.
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DR EMBL; AB110983; BAC77041.1; -; mRNA.
DR EMBL; AP003347; BAD82152.1; -; Genomic_DNA.
DR EMBL; AP008207; BAF05802.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS73726.1; -; Genomic_DNA.
DR EMBL; CM000138; EEE55188.1; -; Genomic_DNA.
DR EMBL; AK102997; BAG95826.1; -; mRNA.
DR RefSeq; XP_015612928.1; XM_015757442.1. [Q5N8Q4-1]
DR RefSeq; XP_015612935.1; XM_015757449.1. [Q5N8Q4-2]
DR AlphaFoldDB; Q5N8Q4; -.
DR SMR; Q5N8Q4; -.
DR STRING; 4530.OS01T0683400-01; -.
DR PaxDb; Q5N8Q4; -.
DR PRIDE; Q5N8Q4; -.
DR EnsemblPlants; Os01t0683400-01; Os01t0683400-01; Os01g0683400. [Q5N8Q4-1]
DR GeneID; 4324139; -.
DR Gramene; Os01t0683400-01; Os01t0683400-01; Os01g0683400. [Q5N8Q4-1]
DR KEGG; osa:4324139; -.
DR eggNOG; KOG2228; Eukaryota.
DR HOGENOM; CLU_007115_0_1_1; -.
DR InParanoid; Q5N8Q4; -.
DR OMA; KVSTTMQ; -.
DR OrthoDB; 1543398at2759; -.
DR PlantReactome; R-OSA-9640882; Assembly of pre-replication complex.
DR PlantReactome; R-OSA-9645850; Activation of pre-replication complex.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000007752; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR Genevisible; Q5N8Q4; OS.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0009744; P:response to sucrose; IDA:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; PTHR12087; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR PIRSF; PIRSF007858; ORC4; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; DNA replication; DNA-binding;
KW Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..470
FT /note="Origin of replication complex subunit 4"
FT /id="PRO_0000431434"
FT BINDING 63..70
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 72..116
FT /note="Missing (in isoform 2)"
FT /id="VSP_057261"
FT CONFLICT 125
FT /note="L -> P (in Ref. 1; BAC77041)"
FT /evidence="ECO:0000305"
FT CONFLICT 354
FT /note="S -> G (in Ref. 1; BAC77041)"
FT /evidence="ECO:0000305"
FT CONFLICT 444..451
FT /note="RELAESLK -> LELADSLN (in Ref. 1; BAC77041)"
FT /evidence="ECO:0000305"
FT CONFLICT 460
FT /note="L -> F (in Ref. 1; BAC77041)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 470 AA; 53023 MW; 90F16CBB4211525F CRC64;
MAAAAAAASV ASQAQAVLRG RLCDQAVVHS ALRSSPDTNY SKLKYLVASS VSEACNNSVL
LLGPRGCGKA AVRFSFLVYS SAPLSAVFSD AGVVFDEMCQ WAIYDFTLWV VSAWTEVVDM
VLDDLKKDHP DAISVIRLNG MLHSDDNCAT KEIARQLCLE HQLSFSKMAS SDDNTEFMID
MLRECGLAHK TIIFVLEEFD LFAQGKQRLL YSLLDAMQSL TSQAVVIGVS CRLDADQLLE
KRVRSRFSHR KLLFVPSSVD SLQRLMEHLL ALPEDSPLPT KYVREYNARI TSIFNDKKFK
GILSSLTDAD ATTSHILRFL FRVVSYMDID SGLLSMQSFM NALSSMQRQP KMDSLQDLSI
LELYILVCMN RLEDKEKSSY NFITIMKEYK SVQDAYKTSD KYSHTVCFRA FEHLLDRELI
SFADNKGRNQ ALEYRPVKLL ISSRELAESL KLNTTCPAVL QKLLDRERYM
