ID   ORC4_XENLA              Reviewed;         432 AA.
AC   O93479;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Origin recognition complex subunit 4;
GN   Name=orc4; Synonyms=orc4l;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RA   Komrskova T., Yang H., Gavin K., Pappin P., Canas B., Kobayashi R.,
RA   Hunt T., Stillman B.;
RT   "Identification of the Orc4p and Orc5p subunits of the Xenopus and human
RT   origin recognition complex.";
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent, however specific
CC       DNA sequences that define origins of replication have not been
CC       identified so far. ORC is required to assemble the pre-replication
CC       complex necessary to initiate DNA replication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: ORC is composed of six subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000305}.
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DR   EMBL; Y16385; CAA76187.1; -; mRNA.
DR   AlphaFoldDB; O93479; -.
DR   SMR; O93479; -.
DR   IntAct; O93479; 2.
DR   MaxQB; O93479; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR016527; ORC4.
DR   InterPro; IPR032705; ORC4_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12087; PTHR12087; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF14629; ORC4_C; 1.
DR   PIRSF; PIRSF007858; ORC4; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; DNA replication; DNA-binding; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..432
FT                   /note="Origin recognition complex subunit 4"
FT                   /id="PRO_0000127089"
FT   BINDING         65..72
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   432 AA;  49411 MW;  C1523AC62BFF00B7 CRC64;
     MSKRKSKDLC LPVGECISKV HGILRQRLFQ HHGKPFGVDS QHKHLVELLK RTVIHGESNS
     ALIIGPRGSG KSMLLKGALE DIFGMKQMKE TALQVNLNGL LQTTDKIALK EITRQLHLEN
     VVGDRVFGSF AENLSFLLEA LKTGDRKSSC PVLFVLDEFD LFAHHKNQTL LYNLFDIAQS
     AQTPVAVIGL TCRLDVMELL EKRVKSRFSH RQIHLLNSFS FSQYLQIFQE KLSLPASFPD
     SQFAEKWNES IKSLVESKLV EDVLQKQYNA SKDVRSLHML MLLAVCRVNV SHPHITAADF
     LEVFRLRNQD SKANILHGVS VLELCLIIAM KHLQDIYDGE PFNFQMVHNE FQKFIQRKAH
     SVYNFEKAVV IKAFEHLHQL ELIKPMEGLS VRTQKEYRLM KLLLDNTQIV EALQKYPNCP
     TDVKQWAMSS LS