ORC5_ORYSJ
ID ORC5_ORYSJ Reviewed; 524 AA.
AC Q10CI8; A0A0P0W393; B9F5T4; Q852R2; Q94HA9;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Origin of replication complex subunit 1 {ECO:0000303|PubMed:15939553};
DE Short=OsORC1 {ECO:0000303|PubMed:15939553};
GN Name=ORC5 {ECO:0000303|PubMed:15939553};
GN OrderedLocusNames=LOC_Os03g55200 {ECO:0000305}, Os03g0759500 {ECO:0000305};
GN ORFNames=OsJ_12664 {ECO:0000312|EMBL:EEE59967.1},
GN OSJNBb0048A17.14 {ECO:0000312|EMBL:AAK63931.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947 {ECO:0000312|Proteomes:UP000059680};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 72-524, INDUCTION BY SUCROSE, TISSUE
RP SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15939553; DOI=10.1016/j.gene.2005.03.047;
RA Mori Y., Yamamoto T., Sakaguchi N., Ishibashi T., Furukawa T., Kadota Y.,
RA Kuchitsu K., Hashimoto J., Kimura S., Sakaguchi K.;
RT "Characterization of the origin recognition complex (ORC) from a higher
RT plant, rice (Oryza sativa L.).";
RL Gene 353:23-30(2005).
RN [8]
RP REVIEW ON THE CORE DNA REPLICATION MACHINERY.
RX PubMed=17556508; DOI=10.1104/pp.107.101105;
RA Shultz R.W., Tatineni V.M., Hanley-Bowdoin L., Thompson W.F.;
RT "Genome-wide analysis of the core DNA replication machinery in the higher
RT plants Arabidopsis and rice.";
RL Plant Physiol. 144:1697-1714(2007).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC sequences that define origins of replication have not been identified
CC yet. ORC is required to assemble the pre-replication complex necessary
CC to initiate DNA replication. {ECO:0000250|UniProtKB:O43913}.
CC -!- SUBUNIT: Component of the origin recognition complex (ORC) composed of
CC at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a
CC cell-cycle and development dependent manner. It is sequentially
CC assembled at the exit from anaphase of mitosis and disassembled as
CC cells enter S phase. {ECO:0000250|UniProtKB:Q6EWX0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43913}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in the shoot apical
CC meristem (SAM), leaves, ears and roots. {ECO:0000269|PubMed:15939553}.
CC -!- INDUCTION: Reduced expression upon sucrose depletion-mediated cell
CC proliferation arrest, and accumulates after sucrose treatment.
CC {ECO:0000269|PubMed:15939553}.
CC -!- SIMILARITY: Belongs to the ORC5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK63931.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC084282; AAK63931.1; ALT_INIT; Genomic_DNA.
DR EMBL; DP000009; ABF98992.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF13253.1; -; Genomic_DNA.
DR EMBL; AP014959; BAS86494.1; -; Genomic_DNA.
DR EMBL; CM000140; EEE59967.1; -; Genomic_DNA.
DR EMBL; AK063449; BAG88711.1; -; mRNA.
DR EMBL; AB099524; BAC55229.1; -; mRNA.
DR RefSeq; XP_015629337.1; XM_015773851.1.
DR AlphaFoldDB; Q10CI8; -.
DR SMR; Q10CI8; -.
DR STRING; 4530.OS03T0759500-01; -.
DR PaxDb; Q10CI8; -.
DR PRIDE; Q10CI8; -.
DR EnsemblPlants; Os03t0759500-01; Os03t0759500-01; Os03g0759500.
DR GeneID; 4334180; -.
DR Gramene; Os03t0759500-01; Os03t0759500-01; Os03g0759500.
DR KEGG; osa:4334180; -.
DR eggNOG; KOG2543; Eukaryota.
DR HOGENOM; CLU_028223_1_0_1; -.
DR InParanoid; Q10CI8; -.
DR OMA; QLRRWHG; -.
DR OrthoDB; 571556at2759; -.
DR PlantReactome; R-OSA-9640882; Assembly of pre-replication complex.
DR PlantReactome; R-OSA-9645850; Activation of pre-replication complex.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000007752; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR Genevisible; Q10CI8; OS.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0009744; P:response to sucrose; IDA:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR020796; ORC5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12705; PTHR12705; 1.
DR Pfam; PF14630; ORC5_C; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; DNA replication; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..524
FT /note="Origin of replication complex subunit 1"
FT /id="PRO_0000431436"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..36
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 90..97
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 48
FT /note="A -> E (in Ref. 5; EEE59967)"
FT /evidence="ECO:0000305"
FT CONFLICT 208
FT /note="V -> F (in Ref. 7; BAC55229)"
FT /evidence="ECO:0000305"
FT CONFLICT 455
FT /note="G -> D (in Ref. 7; BAC55229)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 524 AA; 57388 MW; 6CE37D71C4326B4C CRC64;
MSQPVTPRRT TRSSASASPS PAPASPTSPP KSRPKPSPRR QLLAAAAAPP KEDGSSADAL
LAELPGRRAQ AMDILRLLAP APALPLMLHG GAATGKTRAL LLALRYLRPS QRLVYAALRS
LPSPRALFAS LLSQLSATPF STSSRHRVPD KPSDFVAALR DALNGIVSQG EVVYLVFDNL
EVVRSWDKGG QLLPLLLRLH DLLQLPQVVL VYVSSATPDA YYSMTGSVEP NYVYFPDYTV
DEVRDILMHD HPNPKLYSSF LSVALKPLFR VTRRVDELSA VLEPLFRRYC EPLGDLKAVP
DEGMKRRLFE HVQSHLAVAL NETFNVPMRA SMDEIKDGGS AGKGSAKRQF AGKDGLSSEL
EFHMSVSAKY LLLSAFLASR NPATLDAALF DSTGGLDNRK RKRKSSQASM HMKDTIVEEM
LMKGPGTFPL ERLLAIFQCI TSVSEDILDE IDCPGNMASE SGTTGLMSDV LLQLSTLCNS
NFLSKSRSCP LEGSARYRSN IDEDLALKVA RSVNFPLSKY MYRR
