ID   ORC6_BOVIN              Reviewed;         252 AA.
AC   Q2HJF3;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Origin recognition complex subunit 6;
GN   Name=ORC6; Synonyms=ORC6L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC       sequences that define origins of replication have not been identified
CC       yet. ORC is required to assemble the pre-replication complex necessary
CC       to initiate DNA replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of ORC, a complex composed of at least 6 subunits:
CC       ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle
CC       dependent manner. It is sequentially assembled at the exit from
CC       anaphase of mitosis and disassembled as cells enter S phase (By
CC       similarity). Interacts with DBF4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORC6 family. {ECO:0000305}.
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DR   EMBL; BC105472; AAI05473.1; -; mRNA.
DR   RefSeq; NP_001039666.1; NM_001046201.2.
DR   AlphaFoldDB; Q2HJF3; -.
DR   SMR; Q2HJF3; -.
DR   STRING; 9913.ENSBTAP00000002438; -.
DR   PaxDb; Q2HJF3; -.
DR   PRIDE; Q2HJF3; -.
DR   Ensembl; ENSBTAT00000002438; ENSBTAP00000002438; ENSBTAG00000001872.
DR   GeneID; 515476; -.
DR   KEGG; bta:515476; -.
DR   CTD; 23594; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001872; -.
DR   VGNC; VGNC:32451; ORC6.
DR   eggNOG; KOG4557; Eukaryota.
DR   GeneTree; ENSGT00390000007370; -.
DR   HOGENOM; CLU_067825_1_0_1; -.
DR   InParanoid; Q2HJF3; -.
DR   OMA; RMFEKLL; -.
DR   OrthoDB; 1522235at2759; -.
DR   TreeFam; TF101096; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000001872; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0051782; P:negative regulation of cell division; IEA:Ensembl.
DR   InterPro; IPR008721; ORC6.
DR   InterPro; IPR020529; ORC6_met/pln.
DR   PANTHER; PTHR13394; PTHR13394; 1.
DR   Pfam; PF05460; ORC6; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..252
FT                   /note="Origin recognition complex subunit 6"
FT                   /id="PRO_0000245346"
FT   MOD_RES         195
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5N6"
FT   MOD_RES         229
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5N6"
FT   CROSSLNK        210
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5N6"
SQ   SEQUENCE   252 AA;  28080 MW;  11D71BA2D3F75ED2 CRC64;
     MESGLIRRLA PRLGIAEQEV LRKAEEYLRL SRVKCVGLSA RTTETSNAVM CLDLAASCMK
     CPLDRAYLIK LSGLNKKMYQ SCLKSFECLL GLNSNIGIRD LAVQFSCTEA VNLASKILQS
     YESSLPQTQQ VDLDLSRPLF TTAALLSACK ILKLKVDRNK MAATSGVKKA IFDRLCKQLE
     KIGQQIDREA GDSVTPPQKK KKTVIEPSAK EIENVVETLP KPQKDEDLTQ DYEEWKRNIL
     ENAARAQKAA TQ