ORC6_DICDI
ID ORC6_DICDI Reviewed; 469 AA.
AC Q54P62;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Origin recognition complex subunit 6;
DE AltName: Full=Origin replication complex subunit F;
GN Name=orcF; Synonyms=orc6; ORFNames=DDB_G0284771;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: ORC is composed of six subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ORC6 family. {ECO:0000305}.
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DR EMBL; AAFI02000071; EAL65038.1; -; Genomic_DNA.
DR RefSeq; XP_638396.1; XM_633304.1.
DR AlphaFoldDB; Q54P62; -.
DR SMR; Q54P62; -.
DR STRING; 44689.DDB0233113; -.
DR PaxDb; Q54P62; -.
DR EnsemblProtists; EAL65038; EAL65038; DDB_G0284771.
DR GeneID; 8624765; -.
DR KEGG; ddi:DDB_G0284771; -.
DR dictyBase; DDB_G0284771; orcF.
DR eggNOG; KOG4557; Eukaryota.
DR HOGENOM; CLU_583211_0_0_1; -.
DR InParanoid; Q54P62; -.
DR Reactome; R-DDI-68616; Assembly of the ORC complex at the origin of replication.
DR Reactome; R-DDI-68689; CDC6 association with the ORC:origin complex.
DR Reactome; R-DDI-68949; Orc1 removal from chromatin.
DR Reactome; R-DDI-68962; Activation of the pre-replicative complex.
DR PRO; PR:Q54P62; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR008721; ORC6.
DR InterPro; IPR020529; ORC6_met/pln.
DR PANTHER; PTHR13394; PTHR13394; 1.
DR Pfam; PF05460; ORC6; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..469
FT /note="Origin recognition complex subunit 6"
FT /id="PRO_0000328604"
FT REGION 218..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 51970 MW; BB4437D21ED299F4 CRC64;
MDIEDVMNKL SLKNKKVLNR SSEYSRLIKV KRPMGLGPLE MCKPGACIFV ACKELSIELN
KSQLVRVLGT NDKLFEQSIL ALYTILGKKR PPYSIVEISN TFKLNSTICE SSENLLKLYR
TKILGGIEEV QSQFTNIDDG IFSAASVYIM TQQHSINIDH TLLLSLVDCS QETFQRAMNA
ITQCCYQGES IVKLKKTPPK NKQNTILRSP TSILISSSST LNNTTTSTTT TAPKSPIPIP
SLTPISQIKN LTTKPIVSPS SSPLLSSISP PKVLATPTLS SSSSSSSSSS SSLSPPLSSN
PTTDLSSTNE PIVFNISSEL LPIPPTTTFK NDGNENKNNT KNCNIEIIEE ISNVDESPFN
DNSVKKIEQS NPNISNKKRS RDELEKESEL GKSQPPQPQQ QPQQQQQQQK EKSVKNKINE
GDLTLEQERL LIKKKKEQQF NDWKNSDFAK SKPTPVNATK QLTLDSFFK
