ID   ORC6_MOUSE              Reviewed;         262 AA.
AC   Q9WUJ8;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Origin recognition complex subunit 6;
GN   Name=Orc6; Synonyms=Orc6l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Dean F.B., O'Donnell M.;
RT   "cDNA Cloning of a homolog for Saccharomyces cerevisiae ORC6 from Mus
RT   musculus.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INTERACTION WITH DBF4.
RX   PubMed=12614612; DOI=10.1016/s0022-2836(03)00079-2;
RA   Kneissl M., Puetter V., Szalay A.A., Grummt F.;
RT   "Interaction and assembly of murine pre-replicative complex proteins in
RT   yeast and mouse cells.";
RL   J. Mol. Biol. 327:111-128(2003).
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent. The specific DNA
CC       sequences that define origins of replication have not been identified
CC       yet. ORC is required to assemble the pre-replication complex necessary
CC       to initiate DNA replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of ORC, a complex composed of at least 6 subunits:
CC       ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle
CC       dependent manner. It is sequentially assembled at the exit from
CC       anaphase of mitosis and disassembled as cells enter S phase (By
CC       similarity). Interacts with DBF4. {ECO:0000250,
CC       ECO:0000269|PubMed:12614612}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORC6 family. {ECO:0000305}.
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DR   EMBL; AF139659; AAD32667.1; -; mRNA.
DR   CCDS; CCDS22497.1; -.
DR   AlphaFoldDB; Q9WUJ8; -.
DR   SMR; Q9WUJ8; -.
DR   ComplexPortal; CPX-1915; Nuclear origin of replication recognition complex.
DR   CORUM; Q9WUJ8; -.
DR   STRING; 10090.ENSMUSP00000034132; -.
DR   iPTMnet; Q9WUJ8; -.
DR   PhosphoSitePlus; Q9WUJ8; -.
DR   EPD; Q9WUJ8; -.
DR   MaxQB; Q9WUJ8; -.
DR   PaxDb; Q9WUJ8; -.
DR   PRIDE; Q9WUJ8; -.
DR   ProteomicsDB; 293523; -.
DR   MGI; MGI:1929285; Orc6.
DR   eggNOG; KOG4557; Eukaryota.
DR   InParanoid; Q9WUJ8; -.
DR   PhylomeDB; Q9WUJ8; -.
DR   Reactome; R-MMU-176187; Activation of ATR in response to replication stress.
DR   Reactome; R-MMU-68616; Assembly of the ORC complex at the origin of replication.
DR   Reactome; R-MMU-68689; CDC6 association with the ORC:origin complex.
DR   Reactome; R-MMU-68949; Orc1 removal from chromatin.
DR   Reactome; R-MMU-68962; Activation of the pre-replicative complex.
DR   ChiTaRS; Orc6; mouse.
DR   PRO; PR:Q9WUJ8; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q9WUJ8; protein.
DR   GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0000808; C:origin recognition complex; ISO:MGI.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IMP:MGI.
DR   GO; GO:0051782; P:negative regulation of cell division; ISO:MGI.
DR   InterPro; IPR008721; ORC6.
DR   InterPro; IPR020529; ORC6_met/pln.
DR   PANTHER; PTHR13394; PTHR13394; 1.
DR   Pfam; PF05460; ORC6; 1.
PE   1: Evidence at protein level;
KW   DNA replication; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..262
FT                   /note="Origin recognition complex subunit 6"
FT                   /id="PRO_0000127098"
FT   REGION          197..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         239
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5N6"
FT   CROSSLNK        221
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5N6"
SQ   SEQUENCE   262 AA;  29188 MW;  F8D27EF9C87DE16C CRC64;
     MESELVRRLA PRLGLAEPSV LRKAEEFLRL SKVKCVSLSA RSSETSNAVI CLDLAASCRK
     CPLDRAYLIR LSGLNKMMYQ SCLKSFECLL GLNSNVGIRD LAVQFSCTEA VNLAAEILQS
     YKSGLPETQR ADLDLSRPLF TTAALLSACK ILKIKVDKTK MITTSGVKKA ILDRLCKQLE
     KIGQQINRDS ADLARPALKR KKPEFSPTLK KKEPGLEPPA KEIEVIETLH KLPKDEDLTQ
     DYEEWKRKIL ENAAKAQTAT AE