ORC6_SCHPO
ID ORC6_SCHPO Reviewed; 264 AA.
AC O74796; Q1MTP2;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Origin recognition complex subunit 6;
GN Name=orc6; ORFNames=SPBC2A9.12, SPBC2D10.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 3-10; 12-26; 217-236 AND 238-244, AND SUBUNIT.
RC STRAIN=KM1 {ECO:0000269|PubMed:10535928};
RX PubMed=10535928; DOI=10.1073/pnas.96.22.12367;
RA Moon K.-Y., Kong D., Lee J.-K., Raychaudhuri S., Hurwitz J.;
RT "Identification and reconstitution of the origin recognition complex from
RT Schizosaccharomyces pombe.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:12367-12372(1999).
RN [3] {ECO:0000305}
RP CHARACTERIZATION OF ORC, AND INTERACTION WITH CDC18.
RX PubMed=11850415; DOI=10.1074/jbc.m107710200;
RA Chuang R.-Y., Chretien L., Dai J., Kelly T.J.;
RT "Purification and characterization of the Schizosaccharomyces pombe origin
RT recognition complex: interaction with origin DNA and Cdc18 protein.";
RL J. Biol. Chem. 277:16920-16927(2002).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. It has a role in both chromosomal replication
CC and mating type transcriptional silencing. ORC binds to multiple sites
CC within the ars1 origin of DNA replication in an ATP-independent manner.
CC {ECO:0000250|UniProtKB:Q9Y5N6, ECO:0000269|PubMed:10535928,
CC ECO:0000269|PubMed:11850415}.
CC -!- SUBUNIT: ORC is composed of six subunits. ORC interacts with cdc18,
CC recruiting it to the ars1 origin of replication.
CC {ECO:0000269|PubMed:10535928, ECO:0000269|PubMed:11850415}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the ORC6 family. {ECO:0000303|PubMed:10535928}.
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DR EMBL; CU329671; CAB39854.1; -; Genomic_DNA.
DR PIR; T40103; T40103.
DR RefSeq; NP_596222.1; NM_001022141.2.
DR AlphaFoldDB; O74796; -.
DR BioGRID; 276966; 8.
DR STRING; 4896.SPBC2A9.12.1; -.
DR MaxQB; O74796; -.
DR PaxDb; O74796; -.
DR EnsemblFungi; SPBC2A9.12.1; SPBC2A9.12.1:pep; SPBC2A9.12.
DR GeneID; 2540438; -.
DR KEGG; spo:SPBC2A9.12; -.
DR PomBase; SPBC2A9.12; orc6.
DR VEuPathDB; FungiDB:SPBC2A9.12; -.
DR eggNOG; ENOG502SGNU; Eukaryota.
DR HOGENOM; CLU_1074255_0_0_1; -.
DR OMA; RPYMAAH; -.
DR Reactome; R-SPO-176187; Activation of ATR in response to replication stress.
DR Reactome; R-SPO-68616; Assembly of the ORC complex at the origin of replication.
DR Reactome; R-SPO-68689; CDC6 association with the ORC:origin complex.
DR Reactome; R-SPO-68949; Orc1 removal from chromatin.
DR Reactome; R-SPO-68962; Activation of the pre-replicative complex.
DR PRO; PR:O74796; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IC:PomBase.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IDA:UniProtKB.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IC:PomBase.
DR GO; GO:0043596; C:nuclear replication fork; IC:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0003688; F:DNA replication origin binding; IDA:UniProtKB.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IC:PomBase.
DR InterPro; IPR008721; ORC6.
DR InterPro; IPR020529; ORC6_met/pln.
DR PANTHER; PTHR13394; PTHR13394; 1.
DR Pfam; PF05460; ORC6; 2.
PE 1: Evidence at protein level;
KW Direct protein sequencing; DNA replication; DNA-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..264
FT /note="Origin recognition complex subunit 6"
FT /id="PRO_0000127101"
SQ SEQUENCE 264 AA; 30703 MW; 79F455EA9898939A CRC64;
MERQQIIESL RRIIPTESTE YNERLISLGE SFLEWSKYKH NLKATEELCR PYMAAHLACE
LLSNDLNLEI NLLATPIPKK KYYKLFTYFQ EILSPLTKSL AAKDDLMETI TYLCTKLGGS
TAIPYVKQLV KAVVTNDMRI EHKRGIIIAA YLLVSAKAFG KDELHINHTE RRKAQSVLQD
TSSALQIQYW MHVLSESWQY KEIPLNGIEG YESQKQRIKP WSGIASMIQI DYEKRLQNYP
IWKACIEERI QYYKSQLEKD GTAS
