ID   ORCK1_APIME             Reviewed;         147 AA.
AC   P85832;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Orcokinin peptides;
DE   Contains:
DE     RecName: Full=Orcokinin-like peptide-1;
DE     AltName: Full=Brain peptide NIDEIDRTAFDNFF;
DE   Contains:
DE     RecName: Full=Orcokinin-like peptide-2;
DE     AltName: Full=Brain peptide IDEIDRTAFDNFF;
DE   Contains:
DE     RecName: Full=Orcokinin-like peptide-3;
DE     AltName: Full=Brain peptide EIDRTAFDNFF;
DE   Contains:
DE     RecName: Full=Brain peptide NLDEIDRVGWSGFV;
DE   Contains:
DE     RecName: Full=Brain peptide LTNYLATTGHGTNTGGPVLT;
DE   Flags: Precursor;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DH4;
RG   Honey bee genome project;
RA   Zhang L., Deng J., Wu Y.-Q., Kovar C., Aqrawi P., Bandaranaike D.,
RA   Blankenburg K., Chen D., Denson S., Dinh H., Firestine M., Gross S.,
RA   Han Y., Hernandez B., Holder M., Jackson L., Javaid M., Jing C., Jones J.,
RA   Joshi V., Kamau G., Korchina V., Lee S., Lorensuhewa L., Mata R.,
RA   Mathew T., Mims S., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA   Pham C., Puazo M., Qu C., Quiroz J., Raj R., Rio Deiros D., Santibanez J.,
RA   Scheel M., Scherer S., Vee V., Wang M., Xin Y., Richards S., Reid J.G.,
RA   Newsham I., Worley K.C., Muzny D.M., Gibbs R.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 92-105; 108-121 AND 124-143, AND MASS SPECTROMETRY.
RC   TISSUE=Brain {ECO:0000269|PubMed:17068263};
RX   PubMed=17068263; DOI=10.1126/science.1124128;
RA   Hummon A.B., Richmond T.A., Verleyen P., Baggerman G., Huybrechts J.,
RA   Ewing M.A., Vierstraete E., Rodriguez-Zas S.L., Schoofs L., Robinson G.E.,
RA   Sweedler J.V.;
RT   "From the genome to the proteome: uncovering peptides in the Apis brain.";
RL   Science 314:647-649(2006).
CC   -!- FUNCTION: Myotropic peptides. {ECO:0000250|UniProtKB:Q9NL83}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9NL83}.
CC   -!- MASS SPECTROMETRY: [Orcokinin-like peptide-1]: Mass=1715.78;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC   -!- MASS SPECTROMETRY: [Orcokinin-like peptide-2]: Mass=1601.74;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC   -!- MASS SPECTROMETRY: [Orcokinin-like peptide-3]: Mass=1373.63;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC   -!- MASS SPECTROMETRY: [Brain peptide NLDEIDRVGWSGFV]: Mass=1605.79;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC   -!- MASS SPECTROMETRY: [Brain peptide LTNYLATTGHGTNTGGPVLT]: Mass=1987;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC   -!- SIMILARITY: Belongs to the orcokinin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AADG06001921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P85832; -.
DR   PaxDb; P85832; -.
DR   eggNOG; ENOG502RTRH; Eukaryota.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PROPEP          28..89
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT                   /id="PRO_0000339276"
FT   PEPTIDE         92..105
FT                   /note="Orcokinin-like peptide-1"
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT                   /id="PRO_0000339277"
FT   PEPTIDE         93..105
FT                   /note="Orcokinin-like peptide-2"
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT                   /id="PRO_0000339278"
FT   PEPTIDE         95..105
FT                   /note="Orcokinin-like peptide-3"
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT                   /id="PRO_0000339279"
FT   PEPTIDE         108..121
FT                   /note="Brain peptide NLDEIDRVGWSGFV"
FT                   /id="PRO_0000339280"
FT   PEPTIDE         124..143
FT                   /note="Brain peptide LTNYLATTGHGTNTGGPVLT"
FT                   /id="PRO_0000339281"
FT   PROPEP          146..147
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT                   /id="PRO_0000339282"
SQ   SEQUENCE   147 AA;  16621 MW;  DC7E5B44BBA4BBAC CRC64;
     MPRHSVFALS ILALSITATV WIPTVQAETN LLRREFYGPV NPELFAAFLD DHDARGRENQ
     RDFSSGSGTN ELVDELSPVS ERETLERFGK RNIDEIDRTA FDNFFKRNLD EIDRVGWSGF
     VKRLTNYLAT TGHGTNTGGP VLTRRFG