ORCKA_PROCL
ID ORCKA_PROCL Reviewed; 251 AA.
AC Q9NL83;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Orcokinin peptides type A;
DE Contains:
DE RecName: Full=Orcomyotropin-like peptide;
DE Contains:
DE RecName: Full=Orcokinin;
DE Contains:
DE RecName: Full=Orcokinin-like peptide 1;
DE Contains:
DE RecName: Full=Orcokinin-like peptide 2;
DE Contains:
DE RecName: Full=Orcokinin-like peptide 3;
DE Contains:
DE RecName: Full=Orcokinin-like peptide 4;
DE Flags: Precursor;
OS Procambarus clarkii (Red swamp crayfish).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC Astacoidea; Cambaridae; Procambarus.
OX NCBI_TaxID=6728 {ECO:0000312|EMBL:BAA94753.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND MASS SPECTROMETRY.
RC TISSUE=Olfactory bulb {ECO:0000269|PubMed:10753578};
RX PubMed=10753578; DOI=10.1006/gcen.1999.7453;
RA Yasuda-Kamatani Y., Yasuda A.;
RT "Identification of orcokinin gene-related peptides in the brain of the
RT crayfish Procambarus clarkii by the combination of MALDI-TOF and on-line
RT capillary HPLC/Q-Tof mass spectrometries and molecular cloning.";
RL Gen. Comp. Endocrinol. 118:161-172(2000).
CC -!- FUNCTION: Myotropic peptides that enhance both the frequency and
CC amplitude of spontaneous hindgut contractions. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MASS SPECTROMETRY: [Orcomyotropin-like peptide]: Mass=1382.67;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC -!- MASS SPECTROMETRY: [Orcokinin-like peptide 1]: Mass=1475.17;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC -!- MASS SPECTROMETRY: [Orcokinin]: Mass=1518.17; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10753578};
CC -!- MASS SPECTROMETRY: [Orcokinin-like peptide 2]: Mass=1503.28;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC -!- MASS SPECTROMETRY: [Orcokinin-like peptide 3]: Mass=1371.55;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC -!- MASS SPECTROMETRY: [Orcokinin-like peptide 4]: Mass=1555.58;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC -!- SIMILARITY: Belongs to the orcokinin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB029168; BAA94753.1; -; mRNA.
DR AlphaFoldDB; Q9NL83; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; NAS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR040384; FCAP.
DR PANTHER; PTHR33864; PTHR33864; 3.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Neuropeptide; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..46
FT /evidence="ECO:0000269|PubMed:10753578"
FT /id="PRO_0000021918"
FT PEPTIDE 49..59
FT /note="Orcomyotropin-like peptide"
FT /id="PRO_0000021919"
FT PEPTIDE 62..74
FT /note="Orcokinin-like peptide 1"
FT /id="PRO_0000021920"
FT PEPTIDE 77..89
FT /note="Orcokinin"
FT /id="PRO_0000021921"
FT PEPTIDE 92..104
FT /note="Orcokinin"
FT /id="PRO_0000021922"
FT PEPTIDE 107..119
FT /note="Orcokinin"
FT /id="PRO_0000021923"
FT PEPTIDE 122..134
FT /note="Orcokinin"
FT /id="PRO_0000021924"
FT PEPTIDE 137..149
FT /note="Orcokinin"
FT /id="PRO_0000021925"
FT PEPTIDE 152..164
FT /note="Orcokinin"
FT /id="PRO_0000021926"
FT PEPTIDE 167..179
FT /note="Orcokinin-like peptide 2"
FT /id="PRO_0000021927"
FT PEPTIDE 182..192
FT /note="Orcokinin-like peptide 3"
FT /id="PRO_0000021928"
FT PEPTIDE 195..207
FT /note="Orcokinin"
FT /id="PRO_0000021929"
FT PEPTIDE 210..222
FT /note="Orcokinin-like peptide 4"
FT /id="PRO_0000021930"
FT PROPEP 225..231
FT /evidence="ECO:0000269|PubMed:10753578"
FT /id="PRO_0000021931"
FT PEPTIDE 234..246
FT /note="Orcokinin-like peptide 2"
FT /id="PRO_0000021932"
FT PROPEP 249..251
FT /evidence="ECO:0000269|PubMed:10753578"
FT /id="PRO_0000021933"
SQ SEQUENCE 251 AA; 29057 MW; E82A31ED679BAB4C CRC64;
MTAQMFTIAL LLSLSAIAAA GTIKTAPART PSTQDDASFP PDGAPVKRFD AFTTGFGHSK
RNFDEIDRSG FGFAKKNFDE IDRSGFGFNK RNFDEIDRSG FGFNKRNFDE IDRSGFGFNK
RNFDEIDRSG FGFNKRNFDE IDRSGFGFNK RNFDEIDRSG FGFNKRNFDE IDRSGFGFVK
RVYVPRYIAN LYKRNFDEID RSGFGFNKRN FDEIDRTGFG FHKRDYDVFP DKRNFDEIDR
SGFGFVRRNV E