ID   ORCKB_PROCL             Reviewed;         266 AA.
AC   Q9NL82;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Orcokinin peptides type B;
DE   Contains:
DE     RecName: Full=Orcomyotropin-like peptide;
DE   Contains:
DE     RecName: Full=Orcokinin-like peptide 1;
DE   Contains:
DE     RecName: Full=Orcokinin;
DE   Contains:
DE     RecName: Full=Orcokinin-like peptide 2;
DE   Contains:
DE     RecName: Full=Orcokinin-like peptide 3;
DE   Contains:
DE     RecName: Full=Orcokinin-like peptide 4;
DE   Flags: Precursor;
OS   Procambarus clarkii (Red swamp crayfish).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Astacoidea; Cambaridae; Procambarus.
OX   NCBI_TaxID=6728 {ECO:0000312|EMBL:BAA94754.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND MASS SPECTROMETRY.
RC   TISSUE=Olfactory bulb {ECO:0000269|PubMed:10753578};
RX   PubMed=10753578; DOI=10.1006/gcen.1999.7453;
RA   Yasuda-Kamatani Y., Yasuda A.;
RT   "Identification of orcokinin gene-related peptides in the brain of the
RT   crayfish Procambarus clarkii by the combination of MALDI-TOF and on-line
RT   capillary HPLC/Q-Tof mass spectrometries and molecular cloning.";
RL   Gen. Comp. Endocrinol. 118:161-172(2000).
CC   -!- FUNCTION: Myotropic peptides that enhance both the frequency and
CC       amplitude of spontaneous hindgut contractions. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: [Orcomyotropin-like peptide]: Mass=1382.67;
CC       Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC   -!- MASS SPECTROMETRY: [Orcokinin-like peptide 1]: Mass=1475.17;
CC       Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC   -!- MASS SPECTROMETRY: [Orcokinin]: Mass=1518.17; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10753578};
CC   -!- MASS SPECTROMETRY: [Orcokinin-like peptide 2]: Mass=1503.28;
CC       Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC   -!- MASS SPECTROMETRY: [Orcokinin-like peptide 3]: Mass=1371.55;
CC       Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC   -!- MASS SPECTROMETRY: [Orcokinin-like peptide 4]: Mass=1555.58;
CC       Method=MALDI; Evidence={ECO:0000269|PubMed:10753578};
CC   -!- SIMILARITY: Belongs to the orcokinin family. {ECO:0000305}.
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DR   EMBL; AB029169; BAA94754.1; -; mRNA.
DR   AlphaFoldDB; Q9NL82; -.
DR   PRIDE; Q9NL82; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; NAS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR040384; FCAP.
DR   PANTHER; PTHR33864; PTHR33864; 3.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..46
FT                   /evidence="ECO:0000269|PubMed:10753578"
FT                   /id="PRO_0000021934"
FT   PEPTIDE         49..59
FT                   /note="Orcomyotropin-like peptide"
FT                   /id="PRO_0000021935"
FT   PEPTIDE         62..74
FT                   /note="Orcokinin-like peptide 1"
FT                   /id="PRO_0000021936"
FT   PEPTIDE         77..89
FT                   /note="Orcokinin"
FT                   /id="PRO_0000021937"
FT   PEPTIDE         92..104
FT                   /note="Orcokinin"
FT                   /id="PRO_0000021938"
FT   PEPTIDE         107..119
FT                   /note="Orcokinin"
FT                   /id="PRO_0000021939"
FT   PEPTIDE         122..134
FT                   /note="Orcokinin"
FT                   /id="PRO_0000021940"
FT   PEPTIDE         137..149
FT                   /note="Orcokinin"
FT                   /id="PRO_0000021941"
FT   PEPTIDE         152..164
FT                   /note="Orcokinin"
FT                   /id="PRO_0000021942"
FT   PEPTIDE         167..179
FT                   /note="Orcokinin"
FT                   /id="PRO_0000021943"
FT   PEPTIDE         182..194
FT                   /note="Orcokinin-like peptide 2"
FT                   /id="PRO_0000021944"
FT   PEPTIDE         197..207
FT                   /note="Orcokinin-like peptide 3"
FT                   /id="PRO_0000021945"
FT   PEPTIDE         210..222
FT                   /note="Orcokinin"
FT                   /id="PRO_0000021946"
FT   PEPTIDE         225..237
FT                   /note="Orcokinin-like peptide 4"
FT                   /id="PRO_0000021947"
FT   PROPEP          240..246
FT                   /evidence="ECO:0000269|PubMed:10753578"
FT                   /id="PRO_0000021948"
FT   PEPTIDE         249..261
FT                   /note="Orcokinin-like peptide 2"
FT                   /id="PRO_0000021949"
FT   PROPEP          264..266
FT                   /evidence="ECO:0000269|PubMed:10753578"
FT                   /id="PRO_0000021950"
SQ   SEQUENCE   266 AA;  30841 MW;  7145EFC226CCEE29 CRC64;
     MTAQMFTIAL LLSLSAIAAA GTIKTAPART PSTQDDASFP PDGAPVKRFD AFTTGFGHSK
     RNFDEIDRSG FGFAKKNFDE IDRSGFGFNK RNFDEIDRSG FGFNKRNFDE IDRSGFGFNK
     RNFDEIDRSG FGFNKRNFDE IDRSGFGFNK RNFDEIDRSG FGFNKRNFDE IDRSGFGFNK
     RNFDEIDRSG FGFVKRVYVP RYIANLYKRN FDEIDRSGFG FNKRNFDEID RTGFGFHKRD
     YDVFPDKRNF DEIDRSGFGF VRRNVE