ID   ASAI_AERSA              Reviewed;         207 AA.
AC   P70774;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Acyl-homoserine-lactone synthase;
DE            EC=2.3.1.184;
DE   AltName: Full=Autoinducer synthesis protein AsaI;
GN   Name=asaI;
OS   Aeromonas salmonicida.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=645;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33658 / DSM 19634 / JCM 7874 / NCIMB 1102 / NCTC 12959;
RX   PubMed=9286976; DOI=10.1128/jb.179.17.5271-5281.1997;
RA   Swift S., Karlyshev A.V., Fish L., Durant E.L., Winson M.K., Chhabra S.R.,
RA   Williams P., Macintyre S., Stewart G.S.A.B.;
RT   "Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida:
RT   identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-
RT   acylhomoserine lactone signal molecules.";
RL   J. Bacteriol. 179:5271-5281(1997).
CC   -!- FUNCTION: Required for the synthesis of N-butanoyl-L-homoserine lactone
CC       (BHL), an autoinducer molecule which binds to AsaR.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the autoinducer synthase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00533}.
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DR   EMBL; U65741; AAB70017.1; -; Genomic_DNA.
DR   RefSeq; WP_005315937.1; NZ_UFSF01000001.1.
DR   AlphaFoldDB; P70774; -.
DR   SMR; P70774; -.
DR   STRING; 1233098.GCA_000315855_00759; -.
DR   OMA; YMLKDTF; -.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR018311; Autoind_synth_CS.
DR   InterPro; IPR001690; Autoind_synthase.
DR   PANTHER; PTHR39322; PTHR39322; 1.
DR   Pfam; PF00765; Autoind_synth; 1.
DR   PRINTS; PR01549; AUTOINDCRSYN.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS00949; AUTOINDUCER_SYNTH_1; 1.
DR   PROSITE; PS51187; AUTOINDUCER_SYNTH_2; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..207
FT                   /note="Acyl-homoserine-lactone synthase"
FT                   /id="PRO_0000210880"
SQ   SEQUENCE   207 AA;  23616 MW;  3AF4C46B70ED97BE CRC64;
     MLVFKGKLKE HPRWEVENEL YRFRNRVFSD RLGWDVESHR GLEQDSFDTP DTHWVLIEDE
     EGLCGCIRLL SCAQDYMLPS IFPTALAGEA PPRSSDVWEL TRLAIDANRA PRMGNGVSEL
     TCVIFREVYA FARAKGIREL VAVVSLPVER IFRRLGLPIE RLGHRQAVDL GAVRGVGIRF
     HLDERFARAV GHPMQGEYAD ARELVTE