ORCK_RHOPR
ID ORCK_RHOPR Reviewed; 69 AA.
AC B6DT16; P85819; P85820; P85821;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=Orcokinin peptides {ECO:0000303|PubMed:19137558};
DE AltName: Full=Orcoquinin {ECO:0000303|PubMed:19137558, ECO:0000312|EMBL:ACI14296.1};
DE Contains:
DE RecName: Full=Orcokinin-3 {ECO:0000303|PubMed:19137558};
DE Short=Rhopr-OK-3 {ECO:0000303|PubMed:19137558};
DE Contains:
DE RecName: Full=Orcokinin-3(1-11) {ECO:0000303|PubMed:19137558};
DE Short=Rhopr-OK-3(1-11) {ECO:0000303|PubMed:19137558};
DE Contains:
DE RecName: Full=Orcokinin-2 {ECO:0000303|PubMed:19137558};
DE Short=Rhopr-OK-2 {ECO:0000303|PubMed:19137558};
DE Contains:
DE RecName: Full=Orcokinin-2(1-12) {ECO:0000303|PubMed:19137558};
DE Short=Rhopr-OK-2(1-12) {ECO:0000303|PubMed:19137558};
DE Contains:
DE RecName: Full=Orcokinin-1 {ECO:0000303|PubMed:19137558};
DE Short=Rhopr-OK-1 {ECO:0000303|PubMed:19137558};
DE Contains:
DE RecName: Full=Orcokinin-1(1-10) {ECO:0000303|PubMed:19137558};
DE Short=Rhopr-OK-1(1-10) {ECO:0000303|PubMed:19137558};
DE Flags: Precursor;
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249;
RN [1] {ECO:0000312|EMBL:ACI14296.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Ons S., Pomar R.R.;
RT "Orcokinins in Rhodnius prolixus nervous system.";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 49-62, AND MASS SPECTROMETRY.
RC TISSUE=Brain {ECO:0000269|PubMed:19137558};
RX PubMed=19137558; DOI=10.1002/pmic.200800499;
RA Ons S., Richter F., Urlaub H., Pomar R.R.;
RT "The neuropeptidome of Rhodnius prolixus brain.";
RL Proteomics 9:788-792(2009).
CC -!- FUNCTION: Myotropic peptides. {ECO:0000250|UniProtKB:Q9NL83}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9NL83}.
CC -!- MASS SPECTROMETRY: [Orcokinin-3]: Mass=1660.77; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:19137558};
CC -!- MASS SPECTROMETRY: [Orcokinin-3(1-11)]: Mass=1313.58; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:19137558};
CC -!- MASS SPECTROMETRY: [Orcokinin-2]: Mass=1617.43; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:19137558};
CC -!- MASS SPECTROMETRY: [Orcokinin-2(1-12)]: Mass=1371.59; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:19137558};
CC -!- MASS SPECTROMETRY: [Orcokinin-1]: Mass=1615.74; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:19137558};
CC -!- MASS SPECTROMETRY: [Orcokinin-1(1-10)]: Mass=1211.57; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:19137558};
CC -!- SIMILARITY: Belongs to the orcokinin family. {ECO:0000255}.
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DR EMBL; FJ167860; ACI14296.1; -; Genomic_DNA.
DR AlphaFoldDB; B6DT16; -.
DR VEuPathDB; VectorBase:RPRC014678; -.
DR eggNOG; ENOG502SE3G; Eukaryota.
DR HOGENOM; CLU_2006745_0_0_1; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted.
FT PROPEP 1..12
FT /evidence="ECO:0000269|PubMed:19137558"
FT /id="PRO_0000365768"
FT PEPTIDE 15..28
FT /note="Orcokinin-3"
FT /evidence="ECO:0000269|PubMed:19137558"
FT /id="PRO_0000365769"
FT PEPTIDE 15..25
FT /note="Orcokinin-3(1-11)"
FT /evidence="ECO:0000269|PubMed:19137558"
FT /id="PRO_0000365770"
FT PROPEP 29..32
FT /evidence="ECO:0000269|PubMed:19137558"
FT /id="PRO_0000365771"
FT PEPTIDE 33..46
FT /note="Orcokinin-2"
FT /evidence="ECO:0000269|PubMed:19137558"
FT /id="PRO_0000365772"
FT PEPTIDE 33..44
FT /note="Orcokinin-2(1-12)"
FT /evidence="ECO:0000269|PubMed:19137558"
FT /id="PRO_0000365773"
FT PEPTIDE 49..62
FT /note="Orcokinin-1"
FT /evidence="ECO:0000269|PubMed:19137558"
FT /id="PRO_0000365774"
FT PEPTIDE 49..58
FT /note="Orcokinin-1(1-10)"
FT /evidence="ECO:0000269|PubMed:19137558"
FT /id="PRO_0000365775"
FT PROPEP 59..69
FT /evidence="ECO:0000269|PubMed:19137558"
FT /id="PRO_0000365776"
SQ SEQUENCE 69 AA; 8125 MW; 9AB5FA1938EF329B CRC64;
MSFFYSSAYA ADKRNFDEID RSGFNSFIKK KKNFDEIDRS GFDGFVKRNF DEIDRVGFGS
FIKKSEPHH
