ORCO_OOCBI
ID ORCO_OOCBI Reviewed; 478 AA.
AC A0A026W182;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 09-JUL-2014, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Odorant receptor coreceptor {ECO:0000255|RuleBase:RU351113};
GN Name=Orco {ECO:0000303|PubMed:28802042};
GN ORFNames=X777_12371 {ECO:0000312|EMBL:EZA49341.1};
OS Ooceraea biroi (Clonal raider ant) (Cerapachys biroi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Dorylinae; Ooceraea.
OX NCBI_TaxID=2015173;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24508170; DOI=10.1016/j.cub.2014.01.018;
RA Oxley P.R., Ji L., Fetter-Pruneda I., McKenzie S.K., Li C., Hu H.,
RA Zhang G., Kronauer D.J.;
RT "The genome of the clonal raider ant Cerapachys biroi.";
RL Curr. Biol. 24:451-458(2014).
RN [2]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=28802042; DOI=10.1016/j.cell.2017.07.001;
RA Trible W., Olivos-Cisneros L., McKenzie S.K., Saragosti J., Chang N.C.,
RA Matthews B.J., Oxley P.R., Kronauer D.J.C.;
RT "Orco mutagenesis causes loss of antennal lobe glomeruli and impaired
RT social behavior in ants.";
RL Cell 170:727-735(2017).
CC -!- FUNCTION: Odorant coreceptor which complexes with conventional odorant
CC receptors (ORs) to form odorant-sensing units, providing sensitive and
CC prolonged odorant signaling and calcium permeability (By similarity).
CC Obligate coreceptor of all odorant receptors (By similarity). Orco is a
CC universal and integral part of the functional odorant receptor,
CC involved in the dendritic localization of other olfactory receptors.
CC Can form functional ion channels in the absence of an odor-binding
CC odorant receptor (By similarity). Plays a central role in the
CC perception of olfactory stimuli in ants and is essential for ant social
CC organization (PubMed:28802042). Required for pheromone sensing
CC (PubMed:28802042). Also required for the development and maintenance of
CC odorant receptor neurons (ORNs) and of antennal lobe glomeruli
CC (PubMed:28802042). {ECO:0000250|UniProtKB:Q7QCC7,
CC ECO:0000269|PubMed:28802042}.
CC -!- SUBUNIT: Heterodimer with conventional odorant receptors (ORs).
CC {ECO:0000250|UniProtKB:Q7QCC7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Present in antennae (at protein level).
CC {ECO:0000269|PubMed:28802042}.
CC -!- DISRUPTION PHENOTYPE: Impaired behavior and fitness, probably due to
CC loss of pheromone sensing. Ants also display gross neuroanatomical
CC defects in the antennal lobe, with a dramatic decrease in the number of
CC antennal lobe glomeruli. {ECO:0000269|PubMed:28802042}.
CC -!- MISCELLANEOUS: In contrast to other ant species, C.biroi ants reproduce
CC via parthenogenesis, enabling stable germline modifications from the
CC clonal progeny of injected individuals without laboratory crosses.
CC {ECO:0000269|PubMed:28802042}.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC Heteromeric odorant receptor channel (TC 1.A.69) family. Orco
CC subfamily. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Whispers - Issue 197 of
CC November 2017;
CC URL="https://web.expasy.org/spotlight/back_issues/197/";
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DR EMBL; KK107522; EZA49341.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A026W182; -.
DR SMR; A0A026W182; -.
DR STRING; 2015173.A0A026W182; -.
DR OMA; QIYYVLF; -.
DR OrthoDB; 588157at2759; -.
DR Proteomes; UP000053097; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005549; F:odorant binding; IEA:InterPro.
DR GO; GO:0004984; F:olfactory receptor activity; IMP:UniProtKB.
DR GO; GO:0007469; P:antennal development; IMP:UniProtKB.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IMP:UniProtKB.
DR GO; GO:0043695; P:detection of pheromone; IMP:UniProtKB.
DR GO; GO:0042048; P:olfactory behavior; IMP:UniProtKB.
DR GO; GO:0019236; P:response to pheromone; IMP:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0035176; P:social behavior; IMP:UniProtKB.
DR InterPro; IPR004117; 7tm6_olfct_rcpt.
DR PANTHER; PTHR21137; PTHR21137; 1.
DR Pfam; PF02949; 7tm_6; 1.
PE 1: Evidence at protein level;
KW Behavior; Cell membrane; Glycoprotein; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..478
FT /note="Odorant receptor coreceptor"
FT /id="PRO_0000442003"
FT TOPO_DOM 1..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..73
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 74..94
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 134..154
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..190
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 191..211
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 350..370
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 371..382
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 383..403
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 404..454
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 455..475
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 476..478
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT REGION 261..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 478 AA; 54109 MW; C35E3F2B46573CF0 CRC64;
MMKMKQQGLV ADLLPNIRVM KTFGHFVFNY YNDNSSKYLH KVYCCVNLFM LLLQFGLCAV
NLIVESADVD DLTANTITLL FFTHSIVKIC YFAIRSKYFY RTWAIWNNPN SHPLFAESNA
RYHAIALKKM RLLLFLVGGT TMLAAVAWTV LTFFEHPIRK IVDPVTNETE IIELPQLLIR
SFYPFDAGKG ITHVLVLVYQ FYWVLFMLID ANSLDVLFCS WLLFACEQLQ HLKQIMKPLM
ELSATLDTVV PNSSELFKAG SADHLRDGDN PPPPPPPQSD NMLDLDLRNI YSNRQDFTAT
FRPTAGMTFN GGVGPNGLTK KQEALVRSAI KYWVERHKHI VRLVTAVGDA YGFALLLHML
TTTITLTLLA YQATKVNGIN VYAASTIGYI LYTFGQVFLF CIFGNRLIEE STSVMEAAYS
CHWYDGSEEA KTFVQIVCQQ CQKAMSISGA KFFTVSLDLF ASVLGAVVTY FMVLVQLK
