ID   ORF0_VZVD               Reviewed;         129 AA.
AC   Q6F6K2;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   02-JUN-2021, entry version 45.
DE   RecName: Full=Membrane protein 0;
DE   AltName: Full=Membrane ORF0 protein;
DE   AltName: Full=ORF S/L;
GN   ORFNames=ORF0;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- SUBUNIT: Interacts with host ITCH; this interaction probably mediates
CC       ITCH degradation. {ECO:0000250|UniProtKB:Q9E2H5}.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9E2H5}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC       essential for viral particle budding. They recruit proteins of the host
CC       ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC       ESCRT-associated proteins. Contains one L domain: a PPXY motif which is
CC       involved in the interaction with ITCH, a member of the NEDD4 family.
CC       {ECO:0000250|UniProtKB:Q9E2H5}.
CC   -!- SIMILARITY: Belongs to the varicellovirus ORF0 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X04370; CAG46438.1; -; Genomic_DNA.
DR   PRIDE; Q6F6K2; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host Golgi apparatus; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..129
FT                   /note="Membrane protein 0"
FT                   /id="PRO_0000339171"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           44..47
FT                   /note="PPXY motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9E2H5"
SQ   SEQUENCE   129 AA;  14092 MW;  F7FE2203491E4F1D CRC64;
     MATVHYSRRP GTPPVTLTSS PSMDDVATPI PYLPTYAEAV ADAPPPYRSR ESLVFSPPLF
     PHVENGTTQQ SYDCLDCAYD GIHRLQLAFL RIRKCCVPAF LILFGILTLT AVVVAIVAVF
     PEEPPNSTT