ORF10_PENRF
ID ORF10_PENRF Reviewed; 458 AA.
AC W6QB19;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 31.
DE RecName: Full=Transcription factor ORF10 {ECO:0000303|PubMed:27921136};
DE AltName: Full=PR-toxin biosynthesis cluster protein 10 {ECO:0000303|PubMed:27921136};
GN Name=ORF10 {ECO:0000303|PubMed:27921136}; ORFNames=PROQFM164_S02g001474;
OS Penicillium roqueforti (strain FM164).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1365484;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FM164;
RX PubMed=24407037; DOI=10.1038/ncomms3876;
RA Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT "Multiple recent horizontal transfers of a large genomic region in cheese
RT making fungi.";
RL Nat. Commun. 5:2876-2876(2014).
RN [2]
RP FUNCTION.
RX PubMed=27921136; DOI=10.1007/s00253-016-7995-5;
RA Hidalgo P.I., Poirier E., Ullan R.V., Piqueras J., Meslet-Cladiere L.,
RA Coton E., Coton M.;
RT "Penicillium roqueforti PR toxin gene cluster characterization.";
RL Appl. Microbiol. Biotechnol. 101:2043-2056(2017).
CC -!- FUNCTION: Transcription factor that specifically regulates the
CC expression of the gene cluster that mediates the biosynthesis of PR-
CC toxin, a bicyclic sesquiterpene belonging to the eremophilane class and
CC acting as a mycotoxin. {ECO:0000269|PubMed:27921136}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR EMBL; HG792016; CDM31324.1; -; Genomic_DNA.
DR AlphaFoldDB; W6QB19; -.
DR SMR; W6QB19; -.
DR EnsemblFungi; CDM31324; CDM31324; PROQFM164_S02g001474.
DR OrthoDB; 1135484at2759; -.
DR Proteomes; UP000030686; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..458
FT /note="Transcription factor ORF10"
FT /id="PRO_0000451233"
FT DNA_BIND 38..65
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 69..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 49795 MW; 5BF9F3973DED8C05 CRC64;
MFGTLRIGSE KNSVEFIEHA KGEAASRLGG YVFSHSACES CRLKKLRCSG HKSGCDRCRS
QAMKCSYQIG APSNSSRPKS RSHFQPNFSN MSGTAGTSKA PSPLGNDGVD REIGGWEMAE
TDPTGSVVTT TAQFLNSVNQ GEHSNLNDLR QGQRFGGELD YSENELNDIF SNIAYLQPDD
METNVFVGAA NRAVLDAEAF DSMTEPANSM SDDIGDIAAS QPPSADVQSA FMAFDHARTS
SSSSSHQSSD TSASDAFIAT DFDGARSRTD PSTCQCRGSI LRVLAEIESN ILSASPSNMY
AILSYLRQTT AASNDILTCR ICNCRLKFFG LLGIIGEKIT SLSGAIITAF VCRLKEQNES
VDFGKSDSPD KRLDPNRAIQ LCEFQVQSLQ EFKVVSAAVI KLQLKYSVAF VSRTRELAIS
MNHLAQAQSL EKLESRLNEL VIKMQRMVSE VDSDLCDI
