ID   A2MGH_PSEAE             Reviewed;        1516 AA.
AC   Q9HVT2;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Alpha-2-macroglobulin homolog {ECO:0000305};
DE   Flags: Precursor;
GN   OrderedLocusNames=PA4489;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved thioester bond that is characteristic of
CC       the alpha-2-macroglobulins. {ECO:0000305}.
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DR   EMBL; AE004091; AAG07877.1; -; Genomic_DNA.
DR   PIR; F83085; F83085.
DR   RefSeq; NP_253179.1; NC_002516.2.
DR   RefSeq; WP_003112866.1; NZ_QZGE01000004.1.
DR   AlphaFoldDB; Q9HVT2; -.
DR   SMR; Q9HVT2; -.
DR   STRING; 287.DR97_1668; -.
DR   PaxDb; Q9HVT2; -.
DR   PRIDE; Q9HVT2; -.
DR   DNASU; 881072; -.
DR   EnsemblBacteria; AAG07877; AAG07877; PA4489.
DR   GeneID; 881072; -.
DR   KEGG; pae:PA4489; -.
DR   PATRIC; fig|208964.12.peg.4699; -.
DR   PseudoCAP; PA4489; -.
DR   HOGENOM; CLU_004561_0_0_6; -.
DR   InParanoid; Q9HVT2; -.
DR   OMA; YAYYADW; -.
DR   PhylomeDB; Q9HVT2; -.
DR   BioCyc; PAER208964:G1FZ6-4578-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..1516
FT                   /note="Alpha-2-macroglobulin homolog"
FT                   /id="PRO_0000036242"
SQ   SEQUENCE   1516 AA;  167429 MW;  FDCED1561D62C18C CRC64;
     MSNLRRFSRS LAVAALVLLP FAAVQAEDTV EPSGYTPMAG ESFFLLADSS FATDEEARVR
     LEAPGRDYRR YRMEPYGGVD VRLYRIEQPL EFLKRQKNLH RVLAEGQFKG EGLSNTLAYL
     WDNWYRKSRR VMQRAFSYES RQQVTEAVPE LKMGNAMTAP TPYDAQPQYA PIPGLPLVSQ
     FRYPLWDAKP IEPPQDVKLA GSSSEFINVV PGNVYIPLGK LKPGLYLVEA LVGKYRATTV
     VFVSNSVAVS KVAGDELLVW TARKHEGTPV PDTKVLWTDG LGVMSSGNTD ADGLLRLKHA
     SPERSYVIGE DREGGVFVSE NFYYDSEIYD TKIYAFTDRP LYRPGDWVSL KMVGREFKDA
     RQSQAAASAP VRLSVIDASG TVLQSLDLRF DAKSGANGRF QLPENAVAGG YELRFDYRGQ
     TYSSAFRVAE YIKPHFEVAL DLAKPDFKTA EPVKGEIVLL YPDGKPVANA RLQLSLRAQQ
     LSMVDNELQY LGQFPVELSS TELTTDGKGR AAIELPPAEK PSRYMLTIFA SDGAAYRVKT
     SKEILIERGA ARYRLSAPQR FSAAGEKVEF SYASEQPTPL KPSSYQWIRL EDRATDSGPV
     ADGRFALTFE RPGTYSVELR DDKGQLLGAT GHSVSGEGVK SVPGTVEVVF DKPEYRTGEE
     ASALITFPEP VEDALLSLER DKVEATALLS KGADWLRLEK LNPTQYRVWI PVREEFSPNL
     TFSVLYTKGG DYSFQNAGIK VGMPQVEIDI ATDKERYEPG ETVTVTLATR FAGKPVSSHL
     TVSVVDEMVY ALQAEIAPGI DQFFYHPRRN NVRTSASLAF ISYDVALPGS TSAPGRANRS
     ERGVKVLERP RREDVDTAAW QPELVTDAQG KASFSFRMPD SLTRWRITAR AIDDNGQVGQ
     KKQFLRSEKP LYLKWSGPTR FRQGDQPDLG LFVFNQGEQP VKAELLSGPP GSQRSQTLEL
     AKGVNYIPLA QQPLSDGDWS AELRQDGQVR DRLAVRFNLL ADGWQVEQMQ NLSLAAASNP
     LQLPADARDV RLRLADGPAA AYLGNLDDLL EYPYGGVEQT ASQLLPLSIA YPALAGGEPR
     IRDRLRLIMQ NSRLRLVQMA GPDAWFAWWG GDVDGDAFLT AYAYYADWYA SRALEIQLPA
     EHWQRILEPY AKQATQTPLL QRALILAFAR DMQLPVNTLL GGLLNDLANA GEGQARAEPL
     EADDGLVLGD PDSAVGLAAA RVLAVDLARQ LRVAVPAPLA AQAETATQRL REAGLPFTDA
     LLASRSAVDG QQASALLQRL APAQSTLERA LALTWLQGAL AQAPQGKLPQ PPKDWQAQRG
     ASGETYWQWR GRGIPSWVDL DEAPARPLPV ALSYRSAQAP SGQLPVQISR RLLRLVPGEG
     AFEFKVEEVG DKPLSSDELY LDEVTLNVPE DTALRYGMLE LPLPPGADVE RTTWGIKISG
     LAGDEATTLE RARNEPGELF YGVPVDSLSG EQRFRHLVRF SQKGSFNLPP ARYLRLYAPE
     QQALEAKPAL AKVKVE