ID   ORF1_VZVO               Reviewed;         108 AA.
AC   Q4JQX4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   23-FEB-2022, entry version 41.
DE   RecName: Full=Structural protein 1;
DE   AltName: Full=Structural ORF1 protein;
GN   ORFNames=ORF1;
OS   Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=341980;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC   Oka varicella vaccine Biken (V-Oka-Biken);
RX   PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA   Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT   its parental virus.";
RL   J. Virol. 76:11447-11459(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC   Oka varicella vaccine Varivax V-Oka-Merk);
RX   PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA   Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA   Vassilev V.;
RT   "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL   J. Virol. 82:11023-11044(2008).
RN   [3]
RP   SUBCELLULAR LOCATION, PHOSPHORYLATION, SUBUNIT, AND TOPOLOGY.
RX   PubMed=18570967; DOI=10.1016/j.virol.2008.04.039;
RA   Koshizuka T., Sadaoka T., Yoshii H., Yamanishi K., Mori Y.;
RT   "Varicella-zoster virus ORF1 gene product is a tail-anchored membrane
RT   protein localized to plasma membrane and trans-Golgi network in infected
RT   cells.";
RL   Virology 377:289-295(2008).
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:18570967}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}. Host Golgi apparatus membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:18570967}.
CC   -!- SIMILARITY: Belongs to the varicellovirus ORF1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ008354; AAY57620.1; -; Genomic_DNA.
DR   EMBL; DQ008355; AAY57691.1; -; Genomic_DNA.
DR   SMR; Q4JQX4; -.
DR   IntAct; Q4JQX4; 8.
DR   MINT; Q4JQX4; -.
DR   Proteomes; UP000002603; Genome.
DR   Proteomes; UP000008504; Genome.
DR   Proteomes; UP000008505; Genome.
DR   Proteomes; UP000008506; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Host Golgi apparatus; Host membrane; Membrane; Phosphoprotein;
KW   Signal-anchor; Transmembrane; Transmembrane helix; Virion.
FT   CHAIN           1..108
FT                   /note="Structural protein 1"
FT                   /id="PRO_0000385143"
FT   TOPO_DOM        1..77
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000269|PubMed:18570967"
FT   TRANSMEM        78..98
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..108
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000269|PubMed:18570967"
SQ   SEQUENCE   108 AA;  12102 MW;  FCF865BAE45F171F CRC64;
     MSRVSEYGVP EGVRESDSDT DSVFMYQHTE LMQNNASPLV VRARPPAVLI PLVDVPRPRS
     RRKASAQLKM QMDRLCNVLG VVLQMATLAL VTYIAFVVHT RATSCKRE