ID   ORF23_HHV8P             Reviewed;         404 AA.
AC   F5HIM6;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Protein ORF23;
GN   Name=ORF23;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION, INTERACTION WITH ORF34, AND SUBCELLULAR LOCATION.
RX   PubMed=28336944; DOI=10.1038/s41598-017-00401-7;
RA   Nishimura M., Watanabe T., Yagi S., Yamanaka T., Fujimuro M.;
RT   "Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene
RT   expression and virus production.";
RL   Sci. Rep. 7:329-329(2017).
CC   -!- FUNCTION: Plays a role in the expression of late genes.
CC       {ECO:0000269|PubMed:28336944}.
CC   -!- SUBUNIT: Interacts with ORF34. {ECO:0000269|PubMed:28336944}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:28336944}. Host
CC       cytoplasm {ECO:0000269|PubMed:28336944}. Note=Mainly localizes in host
CC       nucleus and partially in host cytosol. {ECO:0000269|PubMed:28336944}.
CC   -!- SIMILARITY: Belongs to the lymphocryptovirus BTRF1 family.
CC       {ECO:0000305}.
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DR   EMBL; AF148805; ABD28874.1; -; Genomic_DNA.
DR   RefSeq; YP_001129376.1; NC_009333.1.
DR   BioGRID; 1777006; 4.
DR   PRIDE; F5HIM6; -.
DR   DNASU; 4961503; -.
DR   GeneID; 4961503; -.
DR   KEGG; vg:4961503; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006772; Herpes_BTRF1.
DR   Pfam; PF04682; Herpes_BTRF1; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Reference proteome.
FT   CHAIN           1..404
FT                   /note="Protein ORF23"
FT                   /id="PRO_0000423796"
SQ   SEQUENCE   404 AA;  45172 MW;  88B4D2382C97FAE4 CRC64;
     MLRVPDVKAS LVEGAARLST GERVFHVLTS PAVAAMVGVS NPEVPMPLLF EKFGTPDSST
     LPLYAARHPE LSLLRIMLSP HPYALRSHLC VGEETASLGV YLHSKPVVRG HEFEDTQILP
     ECRLAITSDQ SYTNFKIIDL PAGCRRVPIH AANKRVVIDE AANRIKVFDP ESPLPRHPIT
     PRAGQTRSIL KHNIAQVCER DIVSLNTDNE AASMFYMIGL RRPRLGESPV CDFNTVTIME
     RANNSITFLP KLKLNRLQHL FLKHVLLRSM GLENIVSCFS SLYGAELAPA KTHEREFFGA
     LLERLKRRVE DAVFCLNTIE DFPFREPIRQ PPDCSKVLIE AMEKYFMMCS PKDRQSAAWL
     GAGVVELICD GNPLSEVLGF LAKYMPIQKE CTGNLLKIYA LLTV