ID   ORF24_HHV8P             Reviewed;         752 AA.
AC   F5HFD2;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 25.
DE   RecName: Full=Protein ORF24;
GN   Name=ORF24;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION, INTERACTION WITH ORF34, MUTAGENESIS OF ARG-328, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=26468530; DOI=10.1128/jvi.02157-15;
RA   Davis Z.H., Hesser C.R., Park J., Glaunsinger B.A.;
RT   "Interaction between ORF24 and ORF34 in the Kaposi's Sarcoma-Associated
RT   Herpesvirus Late Gene Transcription Factor Complex Is Essential for Viral
RT   Late Gene Expression.";
RL   J. Virol. 90:599-604(2016).
CC   -!- FUNCTION: Plays a role in the expression of late viral mRNAs together
CC       with ORF34. {ECO:0000269|PubMed:26468530}.
CC   -!- SUBUNIT: Interacts with ORF34. {ECO:0000269|PubMed:26468530}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL87 family. {ECO:0000305}.
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DR   EMBL; AF148805; ABD28875.1; -; Genomic_DNA.
DR   RefSeq; YP_001129377.1; NC_009333.1.
DR   BioGRID; 1776988; 17.
DR   PRIDE; F5HFD2; -.
DR   DNASU; 4961485; -.
DR   GeneID; 4961485; -.
DR   KEGG; vg:4961485; -.
DR   Proteomes; UP000000942; Genome.
DR   InterPro; IPR004285; Herpes_UL87_C.
DR   Pfam; PF03043; Herpes_UL87; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..752
FT                   /note="Protein ORF24"
FT                   /id="PRO_0000423840"
FT   MUTAGEN         328
FT                   /note="R->A: Marked defects in late gene expression."
FT                   /evidence="ECO:0000269|PubMed:26468530"
SQ   SEQUENCE   752 AA;  85212 MW;  00A36973F10683F1 CRC64;
     MAALEGPLLL PPSASLTTSP QTTCYQATWE SQLEIFCCLA TNSHLQAELT LEGLDKMMQP
     EPTFFACRAI RRLLLGERLH PFIHQEGTLL GKVGRRYSGE GLIIDGGGVF TRGQIDTDNY
     LPAVGSWELT DDCDKPCEFR ELRSLYLPAL LTCTICYKAM FRIVCRYLEF WEFEQCFHAF
     LAVLPHSLQP TIYQNYFALL ESLKHLSFSI MPPASPDAQL HFLKFNISSF MATWGWHGEL
     VSLRRAIAHN VERLPTVLKN LSKQSKHQDV KVNGRDLVGF QLALNQLVSR LHVKIQRKDP
     GPKPYRVVVS TPDCTYYLVY PGTPAIYRLV MCMAVADCIG HSCSGLHPCA NFLGTHETPR
     LLAATLSRIR YAPKDRRAAM KGNLQACFQR YAATDARTLG SSTVSDMLEP TKHVSLENFK
     ITIFNTNMVI NTKISCHVPN TLQKTILNIP RLTNNFVIRK YSVKEPSFTI SVFFSDNMCQ
     GTAININISG DMLHFLFAMG TLKCFLPIRH IFPVSIANWN STLDLHGLEN QYMVRMGRKN
     VFWTTNFPSV VSSKDGLNVS WFKAATATIS KVYGQPLVEQ IRHELAPILT DQHARIDGNK
     NRIFSLLEHR NRSQIQTLHK RFLECLVECC SFLRLDVACI RRAAARGLFD FSKKIISHTK
     SKHECAVLGY KKCNLIPKIY ARNKKTRLDE LGRNANFISF VATTGHRFAA LKPQIVRHAI
     RKLGLHWRHR TAASNEQTPP ADPRVRCVRP LV