ID   ORF2P_POL1M             Reviewed;          65 AA.
AC   P0DTB3;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2020, sequence version 1.
DT   07-OCT-2020, entry version 3.
DE   RecName: Full=ORF2p protein;
OS   Poliovirus type 1 (strain Mahoney).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Picornaviridae; Enterovirus; Enterovirus C.
OX   NCBI_TaxID=12081;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6264310; DOI=10.1038/291547a0;
RA   Kitamura N., Semler B.L., Rothberg P.G., Larsen G.R., Adler C.J.,
RA   Dorner A.J., Emini E.A., Hanecak R., Lee J.J., van der Werf S.,
RA   Anderson C.W., Wimmer E.;
RT   "Primary structure, gene organization and polypeptide expression of
RT   poliovirus RNA.";
RL   Nature 291:547-553(1981).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6272282; DOI=10.1073/pnas.78.8.4887;
RA   Racaniello V.R., Baltimore D.;
RT   "Molecular cloning of poliovirus cDNA and determination of the complete
RT   nucleotide sequence of the viral genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:4887-4891(1981).
RN   [3]
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=31492846; DOI=10.1038/s41467-019-12040-9;
RA   Guo H., Li Y., Liu G., Jiang Y., Shen S., Bi R., Huang H., Cheng T.,
RA   Wang C., Wei W.;
RT   "A second open reading frame in human enterovirus determines viral
RT   replication in intestinal epithelial cells.";
RL   Nat. Commun. 10:4066-4066(2019).
CC   -!- FUNCTION: Facilitates virus release from intestinal cells in vitro,
CC       possibly through the host autophagic pathway.
CC       {ECO:0000269|PubMed:31492846}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasmic vesicle membrane
CC       {ECO:0000250|UniProtKB:P0DTB4}; Single-pass membrane protein.
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DR   EMBL; V01149; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; V01148; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   Proteomes; UP000000356; Genome.
DR   Proteomes; UP000149468; Genome.
DR   GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host cytoplasmic vesicle; Host membrane; Membrane; Reference proteome;
KW   Transmembrane.
FT   CHAIN           1..65
FT                   /note="ORF2p protein"
FT                   /id="PRO_0000449088"
FT   TRANSMEM        22..44
FT                   /evidence="ECO:0000255"
FT   REGION          13..18
FT                   /note="Important for viral replication in intestinal cells"
FT                   /evidence="ECO:0000269|PubMed:31492846"
SQ   SEQUENCE   65 AA;  7186 MW;  DD2B7C9EE2003DEF CRC64;
     MVTITDCYHK ANWIGHPVKV RLIIYLFAGS APLSVFTLST ISTVISIRQL YHNGCSGFIT
     ESGRT