ASAP3_HUMAN
ID ASAP3_HUMAN Reviewed; 903 AA.
AC Q8TDY4; B3KRW0; B4DHH4; Q6P9F4; Q86UY1; Q9NXK2;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3;
DE AltName: Full=Development and differentiation-enhancing factor-like 1;
DE AltName: Full=Protein up-regulated in liver cancer 1;
GN Name=ASAP3; Synonyms=DDEFL1, UPLC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=14654939;
RA Okabe H., Furukawa Y., Kato T., Hasegawa S., Yamaoka Y., Nakamura Y.;
RT "Isolation of development and differentiation enhancing factor-like 1
RT (DDEFL1) as a drug target for hepatocellular carcinomas.";
RL Int. J. Oncol. 24:43-48(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain, Colon mucosa, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.06 ANGSTROMS) OF 416-697 IN COMPLEX WITH ZINC
RP IONS.
RG Structural genomics consortium (SGC);
RT "Structural analysis of gap and ankyrin domains of UPLC1.";
RL Submitted (SEP-2005) to the PDB data bank.
RN [7]
RP VARIANT [LARGE SCALE ANALYSIS] THR-617.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Promotes cell proliferation. {ECO:0000269|PubMed:14654939}.
CC -!- INTERACTION:
CC Q8TDY4; P46108: CRK; NbExp=6; IntAct=EBI-2609717, EBI-886;
CC Q8TDY4; Q86UT5: PDZD3; NbExp=3; IntAct=EBI-2609717, EBI-8744528;
CC Q8TDY4; Q86UT5-3: PDZD3; NbExp=3; IntAct=EBI-2609717, EBI-12092811;
CC Q8TDY4; Q04864: REL; NbExp=3; IntAct=EBI-2609717, EBI-307352;
CC Q8TDY4; Q04864-2: REL; NbExp=3; IntAct=EBI-2609717, EBI-10829018;
CC Q8TDY4; P15884-3: TCF4; NbExp=3; IntAct=EBI-2609717, EBI-13636688;
CC Q8TDY4; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-2609717, EBI-11139477;
CC Q8TDY4; Q12800: TFCP2; NbExp=3; IntAct=EBI-2609717, EBI-717422;
CC Q8TDY4; Q05086-2: UBE3A; NbExp=3; IntAct=EBI-2609717, EBI-10175863;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14654939}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8TDY4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TDY4-2; Sequence=VSP_018013;
CC Name=3;
CC IsoId=Q8TDY4-3; Sequence=VSP_039827;
CC -!- TISSUE SPECIFICITY: Highly expressed in primary hepatocarcinoma.
CC Detected in lung, liver and blood leukocytes.
CC {ECO:0000269|PubMed:14654939}.
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DR EMBL; AB056749; BAB85677.1; -; mRNA.
DR EMBL; AK000206; BAA91008.1; -; mRNA.
DR EMBL; AK092291; BAG52522.1; -; mRNA.
DR EMBL; AK295100; BAG58136.1; -; mRNA.
DR EMBL; AL021154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL357134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471134; EAW95050.1; -; Genomic_DNA.
DR EMBL; BC052305; AAH52305.1; -; mRNA.
DR EMBL; BC060786; AAH60786.1; -; mRNA.
DR CCDS; CCDS235.1; -. [Q8TDY4-1]
DR CCDS; CCDS44087.1; -. [Q8TDY4-3]
DR RefSeq; NP_001137250.1; NM_001143778.1. [Q8TDY4-3]
DR RefSeq; NP_060177.2; NM_017707.3. [Q8TDY4-1]
DR PDB; 2B0O; X-ray; 2.06 A; E/F/G/H=416-697.
DR PDB; 3LVQ; X-ray; 3.38 A; E=416-697.
DR PDB; 3LVR; X-ray; 3.38 A; E=416-697.
DR PDBsum; 2B0O; -.
DR PDBsum; 3LVQ; -.
DR PDBsum; 3LVR; -.
DR AlphaFoldDB; Q8TDY4; -.
DR SMR; Q8TDY4; -.
DR BioGRID; 120756; 25.
DR IntAct; Q8TDY4; 18.
DR STRING; 9606.ENSP00000338769; -.
DR iPTMnet; Q8TDY4; -.
DR PhosphoSitePlus; Q8TDY4; -.
DR BioMuta; ASAP3; -.
DR DMDM; 74751433; -.
DR EPD; Q8TDY4; -.
DR jPOST; Q8TDY4; -.
DR MassIVE; Q8TDY4; -.
DR MaxQB; Q8TDY4; -.
DR PaxDb; Q8TDY4; -.
DR PeptideAtlas; Q8TDY4; -.
DR PRIDE; Q8TDY4; -.
DR ProteomicsDB; 74371; -. [Q8TDY4-1]
DR ProteomicsDB; 74372; -. [Q8TDY4-2]
DR ProteomicsDB; 74373; -. [Q8TDY4-3]
DR Antibodypedia; 30164; 169 antibodies from 25 providers.
DR DNASU; 55616; -.
DR Ensembl; ENST00000336689.8; ENSP00000338769.3; ENSG00000088280.20. [Q8TDY4-1]
DR Ensembl; ENST00000437606.6; ENSP00000408826.2; ENSG00000088280.20. [Q8TDY4-3]
DR Ensembl; ENST00000495646.5; ENSP00000436150.1; ENSG00000088280.20. [Q8TDY4-2]
DR Ensembl; ENST00000634513.1; ENSP00000488934.1; ENSG00000282854.2. [Q8TDY4-2]
DR Ensembl; ENST00000634561.2; ENSP00000488946.1; ENSG00000282854.2. [Q8TDY4-1]
DR Ensembl; ENST00000635198.1; ENSP00000488953.1; ENSG00000282854.2. [Q8TDY4-3]
DR GeneID; 55616; -.
DR KEGG; hsa:55616; -.
DR MANE-Select; ENST00000336689.8; ENSP00000338769.3; NM_017707.4; NP_060177.2.
DR UCSC; uc001bgy.1; human. [Q8TDY4-1]
DR CTD; 55616; -.
DR DisGeNET; 55616; -.
DR GeneCards; ASAP3; -.
DR HGNC; HGNC:14987; ASAP3.
DR HPA; ENSG00000088280; Low tissue specificity.
DR MIM; 616594; gene.
DR neXtProt; NX_Q8TDY4; -.
DR OpenTargets; ENSG00000088280; -.
DR PharmGKB; PA164716179; -.
DR VEuPathDB; HostDB:ENSG00000088280; -.
DR eggNOG; KOG0521; Eukaryota.
DR GeneTree; ENSGT00940000161085; -.
DR HOGENOM; CLU_676064_0_0_1; -.
DR InParanoid; Q8TDY4; -.
DR OMA; LQHTQCI; -.
DR OrthoDB; 751525at2759; -.
DR PhylomeDB; Q8TDY4; -.
DR TreeFam; TF325156; -.
DR PathwayCommons; Q8TDY4; -.
DR SignaLink; Q8TDY4; -.
DR BioGRID-ORCS; 55616; 15 hits in 1078 CRISPR screens.
DR ChiTaRS; ASAP3; human.
DR EvolutionaryTrace; Q8TDY4; -.
DR GenomeRNAi; 55616; -.
DR Pharos; Q8TDY4; Tbio.
DR PRO; PR:Q8TDY4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TDY4; protein.
DR Bgee; ENSG00000088280; Expressed in right ovary and 90 other tissues.
DR ExpressionAtlas; Q8TDY4; baseline and differential.
DR Genevisible; Q8TDY4; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005925; C:focal adhesion; IDA:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0001726; C:ruffle; IDA:UniProtKB.
DR GO; GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IMP:UniProtKB.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IDA:UniProtKB.
DR GO; GO:0051492; P:regulation of stress fiber assembly; IMP:UniProtKB.
DR CDD; cd13251; PH_ASAP; 1.
DR Gene3D; 1.10.220.150; -; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR028775; ASAP3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45854; PTHR45854; 1.
DR PANTHER; PTHR45854:SF1; PTHR45854:SF1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF57863; SSF57863; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; ANK repeat; Coiled coil; Cytoplasm;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..903
FT /note="Arf-GAP with SH3 domain, ANK repeat and PH domain-
FT containing protein 3"
FT /id="PRO_0000232887"
FT DOMAIN 302..394
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 426..551
FT /note="Arf-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REPEAT 585..617
FT /note="ANK 1"
FT REPEAT 621..650
FT /note="ANK 2"
FT ZN_FING 441..464
FT /note="C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REGION 740..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 141..172
FT /evidence="ECO:0000255"
FT COILED 248..275
FT /evidence="ECO:0000255"
FT COMPBIAS 776..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..496
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_018013"
FT VAR_SEQ 142..158
FT /note="DSKKQLEKAWKDYEAKM -> ASLSLGSR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039827"
FT VARIANT 377
FT /note="E -> A (in dbSNP:rs16828486)"
FT /id="VAR_048295"
FT VARIANT 617
FT /note="A -> T (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035612"
FT CONFLICT 319
FT /note="V -> A (in Ref. 5; AAH60786)"
FT /evidence="ECO:0000305"
FT CONFLICT 521
FT /note="E -> G (in Ref. 2; BAA91008)"
FT /evidence="ECO:0000305"
FT CONFLICT 596
FT /note="V -> D (in Ref. 2; BAA91008)"
FT /evidence="ECO:0000305"
FT CONFLICT 802
FT /note="L -> V (in Ref. 2; BAA91008)"
FT /evidence="ECO:0000305"
FT HELIX 424..433
FT /evidence="ECO:0007829|PDB:2B0O"
FT TURN 436..439
FT /evidence="ECO:0007829|PDB:2B0O"
FT TURN 442..444
FT /evidence="ECO:0007829|PDB:2B0O"
FT STRAND 451..453
FT /evidence="ECO:0007829|PDB:2B0O"
FT TURN 454..456
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 462..471
FT /evidence="ECO:0007829|PDB:2B0O"
FT TURN 473..475
FT /evidence="ECO:0007829|PDB:2B0O"
FT STRAND 478..480
FT /evidence="ECO:0007829|PDB:2B0O"
FT TURN 481..483
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 488..496
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 499..506
FT /evidence="ECO:0007829|PDB:2B0O"
FT TURN 507..509
FT /evidence="ECO:0007829|PDB:2B0O"
FT STRAND 512..514
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 524..535
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 548..556
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 560..568
FT /evidence="ECO:0007829|PDB:2B0O"
FT STRAND 573..575
FT /evidence="ECO:0007829|PDB:3LVQ"
FT STRAND 580..582
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 589..595
FT /evidence="ECO:0007829|PDB:2B0O"
FT TURN 599..601
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 602..611
FT /evidence="ECO:0007829|PDB:2B0O"
FT STRAND 620..622
FT /evidence="ECO:0007829|PDB:3LVQ"
FT HELIX 625..631
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 635..643
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 658..665
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 668..680
FT /evidence="ECO:0007829|PDB:2B0O"
FT HELIX 690..696
FT /evidence="ECO:0007829|PDB:2B0O"
SQ SEQUENCE 903 AA; 99155 MW; D5E89518AFC86656 CRC64;
MPEQFSVAEF LAVTAEDLSS PAGAAAFAAK MPRYRGAALA REEILEGDQA ILQRIKKAVR
AIHSSGLGHV ENEEQYREAV ESLGNSHLSQ NSHELSTGFL NLAVFTREVA ALFKNLIQNL
NNIVSFPLDS LMKGQLRDGR QDSKKQLEKA WKDYEAKMAK LEKERDRARV TGGIPGEVAQ
DMQRERRIFQ LHMCEYLLKA GESQMKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLFPFI
EKLAASVHAL HQAQEDELQK LTQLRDSLRG TLQLESREEH LSRKNSGCGY SIHQHQGNKQ
FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSTIN RPPVKLTLLT CQVRPNPEEK
KCFDLVTHNR TYHFQAEDEH ECEAWVSVLQ NSKDEALSSA FLGEPSAGPG SWGSAGHDGE
PHDLTKLLIA EVKSRPGNSQ CCDCGAADPT WLSTNLGVLT CIQCSGVHRE LGVRFSRMQS
LTLDLLGPSE LLLALNMGNT SFNEVMEAQL PSHGGPKPSA ESDMGTRRDY IMAKYVEHRF
ARRCTPEPQR LWTAICNRDL LSVLEAFANG QDFGQPLPGP DAQAPEELVL HLAVKVANQA
SLPLVDFIIQ NGGHLDAKAA DGNTALHYAA LYNQPDCLKL LLKGRALVGT VNEAGETALD
IARKKHHKEC EELLEQAQAG TFAFPLHVDY SWVISTEPGS DSEEDEEEKR CLLKLPAQAH
WASGRLDISN KTYETVASLG AATPQGESED CPPPLPVKNS SRTLVQGCAR HASGDRSEVS
SLSSEAPETP ESLGSPASSS SLMSPLEPGD PSQAPPNSEE GLREPPGTSR PSLTSGTTPS
EMYLPVRFSS ESTRSYRRGA RSPEDGPSAR QPLPRRNVPV GITEGDGSRT GSLPASSVQL
LQD
