ID   ORF2_VZVO               Reviewed;         238 AA.
AC   Q4JQX3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   12-AUG-2020, entry version 21.
DE   RecName: Full=Membrane protein 2;
DE   AltName: Full=Membrane ORF2 protein;
GN   ORFNames=ORF2;
OS   Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=341980;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC   Oka varicella vaccine Biken (V-Oka-Biken);
RX   PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA   Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT   its parental virus.";
RL   J. Virol. 76:11447-11459(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC   Oka varicella vaccine Varivax V-Oka-Merk);
RX   PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA   Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA   Vassilev V.;
RT   "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL   J. Virol. 82:11023-11044(2008).
RN   [3]
RP   PHOSPHORYLATION, AND SUBCELLULAR LOCATION.
RX   PubMed=11884583; DOI=10.1128/jvi.76.7.3575-3578.2002;
RA   Sato H., Pesnicak L., Cohen J.I.;
RT   "Varicella-zoster virus open reading frame 2 encodes a membrane
RT   phosphoprotein that is dispensable for viral replication and for
RT   establishment of latency.";
RL   J. Virol. 76:3575-3578(2002).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000269|PubMed:11884583};
CC       Peripheral membrane protein {ECO:0000269|PubMed:11884583}.
CC   -!- PTM: Phosphorylated by host. {ECO:0000269|PubMed:11884583}.
CC   -!- SIMILARITY: Belongs to the varicellovirus ORF2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ008354; AAY57621.1; -; Genomic_DNA.
DR   EMBL; DQ008355; AAY57692.1; -; Genomic_DNA.
DR   IntAct; Q4JQX3; 2.
DR   Proteomes; UP000002603; Genome.
DR   Proteomes; UP000008504; Genome.
DR   Proteomes; UP000008505; Genome.
DR   Proteomes; UP000008506; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR010741; DUF1314.
DR   Pfam; PF07013; DUF1314; 1.
PE   1: Evidence at protein level;
KW   Host membrane; Membrane; Phosphoprotein.
FT   CHAIN           1..238
FT                   /note="Membrane protein 2"
FT                   /id="PRO_0000385144"
SQ   SEQUENCE   238 AA;  25984 MW;  39F0F759B56B5CA4 CRC64;
     MHVISETLAY GHVPAFIMGS TLVRPSLNAT AEENPASETR CLLRVLAGRT VDLPGGGTLH
     ITCTKTYVII GKYSKPGERL SLARLIGRAM TPGGARTFII LAMKEKRSTT LGYECGTGLH
     LLAPSMGTFL RTHGLSNRDL CLWRGNIYDM HMQRLMFWEN IAQNTTETPC ITSTLTCNLT
     EDSGEAALTT SDRPTLPTLT AQGRPTVSNI RGILKGSPRQ QPVCHRVRFA EPTEGVLM