ID   ORF3_MERS1              Reviewed;         103 AA.
AC   K9N796;
DT   29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   02-JUN-2021, entry version 25.
DE   RecName: Full=Non-structural protein ORF3;
DE            Short=ORF3;
DE   Flags: Precursor;
GN   Name=ORF3;
OS   Middle East respiratory syndrome-related coronavirus (isolate United
OS   Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Merbecovirus.
OX   NCBI_TaxID=1263720;
OH   NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=23078800;
RA   Bermingham A., Chand M.A., Brown C.S., Aarons E., Tong C., Langrish C.,
RA   Hoschler K., Brown K., Galiano M., Myers R., Pebody R.G., Green H.K.,
RA   Boddington N.L., Gopal R., Price N., Newsholme W., Drosten C.,
RA   Fouchier R.A., Zambon M.;
RT   "Severe respiratory illness caused by a novel coronavirus, in a patient
RT   transferred to the United Kingdom from the Middle East, September 2012.";
RL   Eurosurveillance 17:20290-20290(2012).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=24318862; DOI=10.1007/s13238-013-3096-8;
RA   Yang Y., Zhang L., Geng H., Deng Y., Huang B., Guo Y., Zhao Z., Tan W.;
RT   "The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of
RT   Middle East respiratory syndrome coronavirus (MERS-CoV) are potent
RT   interferon antagonists.";
RL   Protein Cell 4:951-961(2013).
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum
CC       {ECO:0000269|PubMed:24318862}.
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DR   EMBL; KC164505; AFY13308.1; -; Genomic_RNA.
DR   BioGRID; 4383880; 10.
DR   IntAct; K9N796; 10.
DR   Proteomes; UP000139997; Genome.
DR   GO; GO:0044165; C:host cell endoplasmic reticulum; IDA:UniProtKB.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..103
FT                   /note="Non-structural protein ORF3"
FT                   /id="PRO_0000422435"
FT   REGION          65..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   103 AA;  11241 MW;  2D01277C7B7A7BE9 CRC64;
     MRVQRPPTLL LVFSLSLLVT AFSKPLYVPE HCQNYSGCML RACIKTAQAD TAGLYTNFRI
     DVPSAESTGT QSVSVDREST STHDGPTEHV TSVNLFDVGY SVN