ID   ASAR_ASPFN              Reviewed;         702 AA.
AC   B8N0F0;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=C6 transcription factor asaR {ECO:0000303|PubMed:29674152};
DE   AltName: Full=Aspergillic acid biosynthesis cluster regulator {ECO:0000303|PubMed:29674152};
GN   Name=asaR {ECO:0000303|PubMed:29674152}; ORFNames=AFLA_023040;
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
RN   [2]
RP   IDENTIFICATION WITHIN THE CLUSTER, AND INDUCTION.
RX   PubMed=23834374; DOI=10.1111/mpp.12056;
RA   Dolezal A.L., Obrian G.R., Nielsen D.M., Woloshuk C.P., Boston R.S.,
RA   Payne G.A.;
RT   "Localization, morphology and transcriptional profile of Aspergillus flavus
RT   during seed colonization.";
RL   Mol. Plant Pathol. 14:898-909(2013).
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND PATHWAY.
RX   PubMed=29674152; DOI=10.1016/j.fgb.2018.04.009;
RA   Lebar M.D., Cary J.W., Majumdar R., Carter-Wientjes C.H., Mack B.M.,
RA   Wei Q., Uka V., De Saeger S., Diana Di Mavungu J.;
RT   "Identification and functional analysis of the aspergillic acid gene
RT   cluster in Aspergillus flavus.";
RL   Fungal Genet. Biol. 116:14-23(2018).
CC   -!- FUNCTION: Transcription factor involved in regulation of gene cluster
CC       that mediates the biosynthesis of aspergillic acid (PubMed:29674152).
CC       {ECO:0000269|PubMed:29674152}.
CC   -!- PATHWAY: Secondary metabolite biosynthesis.
CC       {ECO:0000269|PubMed:29674152}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expressed during the earliest stages of maize kernel
CC       infection (PubMed:23834374). {ECO:0000269|PubMed:23834374}.
CC   -!- DISRUPTION PHENOTYPE: Abolishes the expression of all the 7 aspergillic
CC       acid biosynthesis cluster genes and reduces ferriaspergillin production
CC       (PubMed:29674152). {ECO:0000269|PubMed:29674152}.
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DR   EMBL; EQ963473; EED55033.1; -; Genomic_DNA.
DR   RefSeq; XP_002373815.1; XM_002373774.1.
DR   AlphaFoldDB; B8N0F0; -.
DR   EnsemblFungi; EED55033; EED55033; AFLA_023040.
DR   VEuPathDB; FungiDB:AFLA_023040; -.
DR   eggNOG; ENOG502SMKE; Eukaryota.
DR   HOGENOM; CLU_004083_8_0_1; -.
DR   OMA; FTAIHQP; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..702
FT                   /note="C6 transcription factor asaR"
FT                   /id="PRO_0000444459"
FT   DNA_BIND        59..85
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          629..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   702 AA;  79499 MW;  1E5BB4EBAC3E0527 CRC64;
     MILVSDNQFL HLGALAAWHD RATEHDLYDV QQLSVENFRH PPELSPFLYF THMTMERSCT
     QCHQRKVRCS KTLPCSACVR LGATCRFPTT DANAHRPRRV QKITITDRIA QLERSLTILA
     NSAGPLQGPE NPNVRDTSTT LLPEPPQSPN RAQEVLVPDG ASTRYINETF LSQILDKERA
     LYKVIGTPRE TEEITSGLRP EGLLASSRRP TNWSNELELS RWQSAQLWQI YRNNVDPVVK
     ILHLPTVEPL VYATMNGEGS DDCRALLFAI YFAAVTSLSE VDAANLLGRD RRSCLLDFQA
     RIEKVVIDAA CLDAPTMLSL QALAIYIPVP SLRNRTDFYY ETCLRAHRTS RSGWIMNGVL
     IRAAQSIGLH RDGTHFHLTP FDAEVRRRLW WQIIVLDYRA AEDHGLAVHG FGSRSDTRLP
     LHVNDSDLSP ELRILPGPRA KWTEMSLFLL TSEIAIAFQK VYHTTVDHTD NAQRLQTVQE
     LTAYLESTYL CHCDTNIPIQ KVAWLSTRSL LSKFEFFVYQ LSLNNEQSQE AVSSAAERTL
     ISACACLEQS MELQTDDLLR GFRWLFASYN QFHCLMYVLW HLCAQPTGPH VVRVWNIVDL
     VFNVTENDPT RPDPGPTWKV LQHLREKAAQ RRGNVAMSPP TQAHGPSDER VPESRTAEQH
     SGQELEGTGD GFGDLLAPPL DPSSLTEWIN LSENLGMYRF EP