ID   ORF49_HHV8P             Reviewed;         302 AA.
AC   Q2HR83;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   02-JUN-2021, entry version 42.
DE   RecName: Full=Protein ORF49;
GN   Name=ORF49;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=16501115; DOI=10.1128/jvi.80.6.3062-3070.2006;
RA   Gonzalez C.M., Wong E.L., Bowser B.S., Hong G.K., Kenney S., Damania B.;
RT   "Identification and characterization of the Orf49 protein of Kaposi's
RT   sarcoma-associated herpesvirus.";
RL   J. Virol. 80:3062-3070(2006).
CC   -!- FUNCTION: Plays a role in the activation the host JNK/p38 pathways
CC       necessary for KSHV reactivation from latency and for viral replication.
CC       Induces transcriptional activation through host JUN of several ORF50-
CC       responsive promoters. {ECO:0000269|PubMed:16501115}.
CC   -!- SIMILARITY: Belongs to the herpesviridae BBRF1 family. {ECO:0000305}.
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DR   EMBL; AF148805; ABD28899.1; -; Genomic_DNA.
DR   RefSeq; YP_001129402.1; NC_009333.1.
DR   SMR; Q2HR83; -.
DR   BioGRID; 1776951; 6.
DR   PRIDE; Q2HR83; -.
DR   DNASU; 4961448; -.
DR   GeneID; 4961448; -.
DR   KEGG; vg:4961448; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0019046; P:release from viral latency; IEA:UniProtKB-KW.
DR   InterPro; IPR006878; Herpes_BBRF1.
DR   Pfam; PF04793; Herpes_BBRF1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Viral latency; Viral reactivation from latency.
FT   CHAIN           1..302
FT                   /note="Protein ORF49"
FT                   /id="PRO_0000423798"
SQ   SEQUENCE   302 AA;  34601 MW;  0DBAE5A8B7A2E6AE CRC64;
     MTSRRPLKDH LFNHLFRYHY PSWDQILQEL DTLSVATLNP DCHVPALNVE KTLYLAKTIQ
     ILVQHRQSEP YLVPAARANL AYSLQQLYKL GNDKIRGVIN GMLPLVDAGC IGFERELIKG
     LPRVLTLQYP HTAPLESEPP TADCTEWCLS HFVGASGRLR SEVRDILTTH NGTCAPSFQW
     MASVVKKFFL VETVIYEDFQ DTDFNVQLNL CFFWTAVVQM YQRCIYEQKL VHIISTSLTL
     LKSTARSFFA WYDLYRPNLG SAALVKYTEH LIRALTPDCS DVELGELCSH LHHCKHALFS
     IQ