ID   ORF50_HHV8P             Reviewed;         691 AA.
AC   F5HCV3;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 34.
DE   RecName: Full=Putative transcription activator ORF50;
GN   Name=ORF50;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
CC   -!- FUNCTION: Transcription activation. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae TAF50 family. {ECO:0000305}.
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DR   EMBL; AF148805; ABD28900.1; -; Genomic_DNA.
DR   RefSeq; YP_001129401.1; NC_009333.1.
DR   BioGRID; 1777029; 95.
DR   PRIDE; F5HCV3; -.
DR   DNASU; 4961526; -.
DR   GeneID; 4961526; -.
DR   KEGG; vg:4961526; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IDA:UniProtKB.
DR   GO; GO:0039695; P:DNA-templated viral transcription; IDA:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR004998; Herpes_TAF50.
DR   Pfam; PF03326; Herpes_TAF50; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Early protein; Host nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..691
FT                   /note="Putative transcription activator ORF50"
FT                   /id="PRO_0000423801"
FT   REGION          482..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          626..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..573
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        630..644
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..677
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   691 AA;  73679 MW;  EB6BE1F6B936EA60 CRC64;
     MAQDDKGKKL RRSCVESFVG LSDELKAQLY QCVLLINDAY ETIYDPSDLN RVVEDVCIRI
     MKECSKLGAL CGLFTDINMF NLFCFFRASR MRTKGAAGYN VPCAEASQGI IRILTERILF
     CTEKAFLTAA CSGVSLPPAI CKLLHEIYTE MKAKCLGAWR RLVCNRRPIM ILTSSLLKLY
     NTYDTAGLLS EQSRALCLLV FQPVYLPRIM APLEIMTKGQ LAPENFYSIT GSAEKRRPIT
     TGKVTGLSYP GSGLMPESLI LPILEPGLLP ASMVDLSDVL AKPAVILSAP ALSQFVISKP
     HPNMPHTVSI IPFNPSGTDP AFISTWQAAS QNMVYNTSTA PLKPATGSSQ TVSVKAVAQG
     AVITATTVPQ AMPARGTGGE LPVMSASTPA RDQVAACFVA ENTGDSPDNP SSFLTSCHPC
     DPNTVIVAQQ FQPPQCVTLL QVTCAPSSTP PPDSTVRAPV VQLPTVVPLP ASAFLPALAQ
     PEASGEELPG GHDGDQGVPC RDSTAAATAA EATTPKRKQR SKERSSKKRK ALTVPEADTT
     PSTTTPGTSL GSITTPQDVH ATDVATSEGP SEAQPPLLSL PPPLDVDQSL FALLDEAGPE
     TWDVGSPLSP TDDALLSSIL QGLYQLDTPP PLRSPSPASF GPESPADIPS PSGGEYTQLQ
     PVRATSATPA NEVQESGTLY QLHQWRNYFR D