ID   A2MGH_YERPE             Reviewed;        2004 AA.
AC   Q8ZDJ2; Q0WDV6;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Alpha-2-macroglobulin homolog {ECO:0000305};
DE   Flags: Precursor;
GN   OrderedLocusNames=YPO2573, y1143, YP_1141;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved thioester bond that is characteristic of
CC       the alpha-2-macroglobulins. {ECO:0000305}.
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DR   EMBL; AL590842; CAL21198.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM84721.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS61386.1; -; Genomic_DNA.
DR   PIR; AC0314; AC0314.
DR   RefSeq; YP_002347532.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZDJ2; -.
DR   SMR; Q8ZDJ2; -.
DR   IntAct; Q8ZDJ2; 8.
DR   STRING; 214092.YPO2573; -.
DR   PaxDb; Q8ZDJ2; -.
DR   PRIDE; Q8ZDJ2; -.
DR   DNASU; 1146090; -.
DR   EnsemblBacteria; AAM84721; AAM84721; y1143.
DR   EnsemblBacteria; AAS61386; AAS61386; YP_1141.
DR   KEGG; ype:YPO2573; -.
DR   KEGG; ypk:y1143; -.
DR   KEGG; ypm:YP_1141; -.
DR   PATRIC; fig|214092.21.peg.2998; -.
DR   eggNOG; COG2373; Bacteria.
DR   HOGENOM; CLU_000965_2_0_6; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR   InterPro; IPR041203; Bact_A2M_MG5.
DR   InterPro; IPR041462; Bact_A2M_MG6.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF11974; bMG3; 1.
DR   Pfam; PF17972; bMG5; 1.
DR   Pfam; PF17962; bMG6; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..2004
FT                   /note="Alpha-2-macroglobulin homolog"
FT                   /id="PRO_0000036248"
SQ   SEQUENCE   2004 AA;  224131 MW;  EA9F8A1F7452672C CRC64;
     MLCCLVFKGL LSMDLLRFLL ISPFALIKGL YRLSAYLLRL VGRLLRPVVG NLNWRAPQWM
     TKTANGLHCA FNRSEQWVAK HPKGISAAIV LLMAAASAAF YGYHWYLNRP QPIEPAPMVY
     QETSIRVSAP RTVNYQAQKP EAQPLSLNFM HSAAPITAMG QVVDQGISLT PAIEGEWKWA
     TERTLVFTPK KAWPMGANYQ ITIDTEKLLA PQIKLNQTEL NFTTPAFAYQ LEKAEYYQDP
     QEAQKRSTIF HVQFNAPVDV ASFEKQILLG LVEGKSKSEK KLNFSVVYDE KKLNAWIHSQ
     PLMPMDKGGS VHLSINKGVN ASVAATPTTQ AQNKWVSVPN LYSLAVNSIN ATLVESDNNN
     GERALIIAIS DAVKDKEIKN AVKAWLLPQH NFQAKESAKT STDFYPWDMD DIDDNLLQQS
     TPLALTLNEA EQEYQPIFSF KFDAPSYRTL LIEVNNSLTS VGGYKMPEKI YQIVRVPDYP
     KTLRFMSQGS LLSMQGDKQI SVAARNMTGM KLDIKRVIPS QLQHIVSFKS SEYSSAHFNR
     LSDEYFTEHF QYQTALNNDN PGEINYQGVD LSRYLANNPS ARRGVFLLTL SAWDPEKRDN
     QQHSEEDYDE DQEWVGDSRF VVITDLGIIT KQSQDRSRDV FVQSIHSGLP AADAKVSVVA
     KNGVVLLSQI TDSKGHVHFP ALDAFKNERQ PVMFLVEKEG DVSFLPTRAT YDRNLDFSRF
     DIDGEETPSD PRTLSSYLFS DRGVYRPGDR FNIGLITRTA NWATALDGVP LRAEIRDPRD
     TLMSTLPITL DSSGFNELSY TTGENSPTGE WNVYLYLVGK NNETSMLLGH TTVNVKEFEP
     DRLKVQLQLT PERQQGWVKP QELQANINVQ NLFGTPAQER RVTSRLILRP MYPSFAPFPD
     YLFYENRHNS DGFETELEEQ TTDLQGMATI PLDLKSYADA TYQLQLLSEA FEAGGGRSVA
     ATARVLVSPY DSLVGVKADG DLSYINRDAV RKLNIIAVDP SLNKIALPDL SLSLIEQKYI
     SVLTKQDSGV YKYQSRLKEQ LVSEQPLQIS PTGTDFTLVT QQPGDFILVV KDSQGQVLNR
     ISYTVAGNAN LTRSLDRNTE LKLKLNQAEY LQGEEIEIAI NAPYAGSGLI TIEKDKVYSW
     QWFHSDTTSS VQRIRIPPAM EGNGYINVQF VRDVNSDEIF MSPLSYGVMP FKISTKARQA
     AIELASPSVI KPGEVLPIKV TTDSPQRVVV FAVDEGILQV ARYRLKDPLD YFFRKRELSV
     QSAQILDLIL PEFSKLMALT SAPGGDAGEG LDLHLNPFKR KQDKPVAYWS GITEVNGETT
     FNYPIPDYFN GKIRVMAISA TPDRIGKVQT STTVRDNFIL TPNVPAMVAP GDEFDVTVGV
     SNNLQGLKGK AVDITVRLTP PPQLEVVGEA QHSLSLAEKR ETLVSFRLRA RSALGDAPLV
     FDASYGSQSS RRTVSTSVRP AMPFRTQSVM GRMEGNKHTV TNLRQMFDNY AQRQATASHS
     PLVLTQGLAR YLADYPYYSS EQIVSRSIPL IMQSKHPEMD SALNQNEVRD QLKNMLRILS
     SRQNSTGAIG LWHASPTPDP FVTPYVVQFL LEAKSAGYSL PNDILEGANN ALRLLAARPY
     DDLYSLRLRA FAVYLLTLQG EITTNTLASV QSTLQQLYPD SWQTDLSAIY LASSYRLLKM
     DDEANKLLQP TWKQLGKAYS KAWWTQNYFD PLVQDATRLY LITRHFPEKV SSIPPQALEN
     MVLALRDEHY TTYSSAMSIL ALESYTSQVA AQQDTPETLQ IIEISKSKGI DPNVISTLNG
     LFVQGDFTGE AKAIQFNNYA SAPAWYVVNQ SGYDLQPPKD AISNGLEISR SYTDEQGKPV
     TQVTLGQKVN VHLKIRANAK QGQNNLAIVD LLPGGFEVVQ QTAPEPEFYD NQDDQDEETG
     SGWQSPLMVS GSSWYPDYSD IREDRVIIYG SASTDVKEFI YQIKSTNTGR FVVPPAYGEA
     MYDRNVQALS VGKGHILVVP PEAK