ID   ORF58_HHV8P             Reviewed;         357 AA.
AC   F5HAD1;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 27.
DE   RecName: Full=Protein ORF58;
GN   Name=ORF58;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
CC   -!- FUNCTION: Participates in rearrangement of cellular actin to increase
CC       intercellular contacts and thereby promotes virus cell-to-cell
CC       spreadin$g. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Host cell membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae BMRF2 family. {ECO:0000305}.
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DR   EMBL; AF148805; ABD28913.1; -; Genomic_DNA.
DR   RefSeq; YP_001129415.1; NC_009333.1.
DR   BioGRID; 1776983; 5.
DR   PRIDE; F5HAD1; -.
DR   DNASU; 4961480; -.
DR   GeneID; 4961480; -.
DR   KEGG; vg:4961480; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006727; Herpes_BMRF2.
DR   Pfam; PF04633; Herpes_BMRF2; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Virion.
FT   CHAIN           1..357
FT                   /note="Protein ORF58"
FT                   /id="PRO_0000423809"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   357 AA;  39661 MW;  B086BCEDE0F5F5F7 CRC64;
     MCRLDSERAL SLFSYLSGTL AATPFLWCFI FKALYSFTLF TTEITAVFFW SLPVTHLALI
     CMCLCPAAQK QLDRRLEWIC ASAVFAAVVC AAFSGFTFSR VPFIPGLCVL NCLLLLPYPL
     ATATAVYQAP PIVHRYYELG FCGAFMVYYL LLFKKVFVSG VFWLPFIVFL VGGLLAFRHL
     EQHVYIRAGM QRRRAIFIMP GKYITYSVFQ AWAYCRREVV VFVTLLLATL ISTASIGLLT
     PVLIGLDKYM TLFYVGLLSC VGVSVASRRA LFVLLPLAAV LLTLVHILGS GPDMLLVRSC
     LCCLFLVSML AAMGVEIQLI RRKLHRALNA PQMVLALCTV GNLCISCLLS VINKVVG