ID   ORF5A_EAVBU             Reviewed;          59 AA.
AC   P0DJX9;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2013, sequence version 1.
DT   02-DEC-2020, entry version 13.
DE   RecName: Full=Protein ORF5a;
GN   Name=GP5; ORFNames=5a;
OS   Equine arteritis virus (strain Bucyrus) (EAV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Arnidovirineae; Arteriviridae; Equarterivirinae;
OC   Alphaarterivirus; Alphaarterivirus equid.
OX   NCBI_TaxID=299386;
OH   NCBI_TaxID=9788; Equidae (horses).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1851863; DOI=10.1128/jvi.65.6.2910-2920.1991;
RA   den Boon J.A., Snijder E.J., Chirnside E.D., de Vries A.A.F.,
RA   Horzinek M.C., Spaan W.J.M.;
RT   "Equine arteritis virus is not a togavirus but belongs to the
RT   coronaviruslike superfamily.";
RL   J. Virol. 65:2910-2920(1991).
RN   [2]
RP   IDENTIFICATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21307223; DOI=10.1099/vir.0.029264-0;
RA   Firth A.E., Zevenhoven-Dobbe J.C., Wills N.M., Go Y.Y., Balasuriya U.B.,
RA   Atkins J.F., Snijder E.J., Posthuma C.C.;
RT   "Discovery of a small arterivirus gene that overlaps the GP5 coding
RT   sequence and is important for virus production.";
RL   J. Gen. Virol. 92:1097-1106(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=ORF5a; Synonyms=Protein ORF5a;
CC         IsoId=P0DJX9-1; Sequence=Displayed;
CC       Name=GP5; Synonyms=Glycoprotein 5;
CC         IsoId=P28995-1; Sequence=External;
CC   -!- DISRUPTION PHENOTYPE: Knockout mutants displays reduced infectivity.
CC       {ECO:0000269|PubMed:21307223}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X53459; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   Proteomes; UP000000353; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Alternative initiation; Membrane; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..59
FT                   /note="Protein ORF5a"
FT                   /id="PRO_0000423160"
FT   TRANSMEM        13..33
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   59 AA;  6796 MW;  2AA6BF98692024E1 CRC64;
     MFFYDWYVGL NDVIYDCIAI LALGCAITCL LLILHRSALH RLHLVYADGS RRYCQFAAI