ID   ORF5A_PRRSL             Reviewed;          43 AA.
AC   P0DJZ4;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   11-NOV-2015, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Structural protein ORF5a;
OS   Porcine reproductive and respiratory syndrome virus (strain Lelystad)
OS   (PRRSV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Arnidovirineae; Arteriviridae; Variarterivirinae;
OC   Betaarterivirus; Eurpobartevirus; Betaarterivirus suid 1.
OX   NCBI_TaxID=11049;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8517032; DOI=10.1006/viro.1993.1008;
RA   Meulenberg J.J.M., Hulst M.M., de Meijer E.J., Moonen P.L.J.M.,
RA   den Besten A., de Kluyver E.P., Wensvoort G., Moormann R.J.M.;
RT   "Lelystad virus, the causative agent of porcine epidemic abortion and
RT   respiratory syndrome (PEARS), is related to LDV and EAV.";
RL   Virology 192:62-72(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Boxmeer 10;
RX   PubMed=8438574; DOI=10.1006/viro.1993.1129;
RA   Conzelmann K.K., Visser N., van Woensel P., Thiel H.J.;
RT   "Molecular characterization of porcine reproductive and respiratory
RT   syndrome virus, a member of the arterivirus group.";
RL   Virology 193:329-339(1993).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=21307223; DOI=10.1099/vir.0.029264-0;
RA   Firth A.E., Zevenhoven-Dobbe J.C., Wills N.M., Go Y.Y., Balasuriya U.B.,
RA   Atkins J.F., Snijder E.J., Posthuma C.C.;
RT   "Discovery of a small arterivirus gene that overlaps the GP5 coding
RT   sequence and is important for virus production.";
RL   J. Gen. Virol. 92:1097-1106(2011).
CC   -!- FUNCTION: Minor virion component that plays an essential role in virus
CC       infectivity. {ECO:0000250|UniProtKB:P0DJZ5}.
CC   -!- SUBUNIT: Interacts with proteins GP2B and GP4.
CC       {ECO:0000250|UniProtKB:P0DJZ5}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P0DJZ5}. Host cell
CC       membrane {ECO:0000250|UniProtKB:P0DJZ5}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=ORF5a; Synonyms=Protein ORF5a;
CC         IsoId=P0DJZ4-1; Sequence=Displayed;
CC       Name=GP5; Synonyms=Glycoprotein 5;
CC         IsoId=Q04569-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the arteriviridae ORF5a protein family.
CC       {ECO:0000305}.
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DR   EMBL; M96262; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; L04493; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   PIR; A44281; A44281.
DR   PIR; F45392; F45392.
DR   SMR; P0DJZ4; -.
DR   Proteomes; UP000006687; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Alternative initiation; Host cell membrane; Host membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Virion.
FT   CHAIN           1..43
FT                   /note="Structural protein ORF5a"
FT                   /id="PRO_0000434787"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   43 AA;  5047 MW;  63F7717F296FA64D CRC64;
     MFSQIGAFLD SALLLLVAFF AVYRLVLVLC RWQRRQLDIP IHI