ORF5_MERS1
ID ORF5_MERS1 Reviewed; 224 AA.
AC K9N7D2;
DT 29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2013, sequence version 1.
DT 23-FEB-2022, entry version 31.
DE RecName: Full=Non-structural protein ORF5;
DE Short=ORF5;
GN Name=ORF5;
OS Middle East respiratory syndrome-related coronavirus (isolate United
OS Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Betacoronavirus; Merbecovirus.
OX NCBI_TaxID=1263720;
OH NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=23078800;
RA Bermingham A., Chand M.A., Brown C.S., Aarons E., Tong C., Langrish C.,
RA Hoschler K., Brown K., Galiano M., Myers R., Pebody R.G., Green H.K.,
RA Boddington N.L., Gopal R., Price N., Newsholme W., Drosten C.,
RA Fouchier R.A., Zambon M.;
RT "Severe respiratory illness caused by a novel coronavirus, in a patient
RT transferred to the United Kingdom from the Middle East, September 2012.";
RL Eurosurveillance 17:20290-20290(2012).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24318862; DOI=10.1007/s13238-013-3096-8;
RA Yang Y., Zhang L., Geng H., Deng Y., Huang B., Guo Y., Zhao Z., Tan W.;
RT "The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of
RT Middle East respiratory syndrome coronavirus (MERS-CoV) are potent
RT interferon antagonists.";
RL Protein Cell 4:951-961(2013).
CC -!- FUNCTION: Seems to play a role in the inhibition of host innate immune
CC repsonse. {ECO:0000269|PubMed:24318862}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Host Golgi apparatus
CC {ECO:0000269|PubMed:24318862}. Note=Localizes also in the host
CC perinuclear area.
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DR EMBL; KC164505; AFY13311.1; -; Genomic_RNA.
DR SMR; K9N7D2; -.
DR BioGRID; 4383881; 5.
DR IntAct; K9N7D2; 5.
DR Proteomes; UP000139997; Genome.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0039501; P:suppression by virus of host type I interferon production; IDA:UniProtKB.
DR CDD; cd21645; MERS-CoV-like_ORF5; 1.
DR InterPro; IPR044323; MERS-CoV-like_ORF5.
DR PROSITE; PS51967; COV_VIROPORIN_3A_CD; 1.
DR PROSITE; PS51966; COV_VIROPORIN_3A_TM; 1.
PE 4: Predicted;
KW Host Golgi apparatus; Host membrane; Host-virus interaction;
KW Inhibition of host innate immune response by virus; Membrane;
KW Transmembrane; Transmembrane helix; Viral immunoevasion.
FT CHAIN 1..224
FT /note="Non-structural protein ORF5"
FT /id="PRO_0000422438"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 32..127
FT /note="CoV 3a-like viroporin TM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01311"
FT DOMAIN 131..188
FT /note="CoV 3a-like viroporin CD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01312"
SQ SEQUENCE 224 AA; 25280 MW; 609FD02C7604E48C CRC64;
MAFSASLFKP VQLVPVSPAF HRIESTDSIV FTYIPASGYV AALAVNVCLI PLLLLLRQDT
CRRSIIRTMV LYFLVLYNFL LAIVLVNGVH YPTGSCLIAF LVILIILWFV DRIRFCLMLN
SYIPLFDMRS HFIRVSTVSS HGMVPVIHTK PLFIRNFDQR CSCSRCFYLH SSTYIECTYI
SRFSKISLVS VTDFSLNGNV STVFVPATRD SVPLHIIAPS SLIV
