ID   ORF75_HHV8P             Reviewed;        1296 AA.
AC   Q9QR70;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   23-FEB-2022, entry version 97.
DE   RecName: Full=Protein ORF75;
GN   Name=ORF75;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000305}.
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DR   EMBL; AF148805; AAD46504.1; -; Genomic_DNA.
DR   RefSeq; YP_001129434.1; NC_009333.1.
DR   SMR; Q9QR70; -.
DR   IntAct; Q9QR70; 1.
DR   PRIDE; Q9QR70; -.
DR   GeneID; 4961476; -.
DR   KEGG; vg:4961476; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0043657; C:host cell; IEA:GOC.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0075733; P:intracellular transport of virus; IEA:InterPro.
DR   Gene3D; 3.30.1330.10; -; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   Gene3D; 3.90.650.10; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR010077; Herpes_virus_tegument.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   InterPro; IPR024346; Tegument_herpes_virus_N.
DR   Pfam; PF02769; AIRS_C; 1.
DR   Pfam; PF12818; Tegument_dsDNA; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   SUPFAM; SSF55326; SSF55326; 1.
DR   SUPFAM; SSF56042; SSF56042; 1.
DR   TIGRFAMs; TIGR01739; tegu_FGAM_synt; 1.
PE   4: Predicted;
KW   Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..1296
FT                   /note="Protein ORF75"
FT                   /id="PRO_0000423842"
SQ   SEQUENCE   1296 AA;  141680 MW;  72FCB9CC407E9AEB CRC64;
     MAYDVTGLWL ESDLTADEEA FVSFYTSRTG TLTLVPGGTG GYYLLWITFR RPPTSREERE
     RRDVEIQTVL AVLSPLLGYP HVIRRSPPRG SERVVSFGYG PNINHRPTTL STELGVLLRE
     LGLQEWARVE VGRHLVSKIT QTLLEPHPPQ FIRAFTQNTD LVPYEGLEVP EGPQPVARPH
     IEDDVIMQAV MISLGADLLP LAVQASTGDN YNVARYFVIP GRCTMERWPW NCARQAFGIH
     GAYTHVHSSV QRGIRGLGNL LFHSTLFPGG QTQGALTGLY ATEPALGPRA HSRFRRIFAK
     GVQQAEMLQG AGVPTLGGFL KTVRTIATTP GNALAVCSIS TTTSKECISL RRMIPQQTVV
     CLGRFEPTDG PDTYPNLYRD SSDNAVRILE TLKLVQRLAK GPIFSGLNRS HDPAPVVRHL
     QALAPRTGLE LFVSKLPDEV RAHLPADPAA GPDAVEAAVA EHFLNVYCSL VFAVVAESGA
     VPGDLGETPL EVLQRAARLC ACQITVLGRT SEQPGIRIVD DLTGETTRVF SVDQPSSTPP
     SPWLALSDGV RVSGHPEDVD WGLFATGSTI HQLLRHATVG SKEFFTRHMD RCSNGLIAQQ
     AGVGPLDIPV SDYHLVLHSS MLAERVAPRV PDTVEAITPS MANLLHKDFE TWVKALPQEL
     LPVPAWRGQA MAMGEQAYKM ATNVSTGATY AITEALTNLM FSPVSKLQDV VLTGAVAWSP
     EDHQAGLLQE CLFACKEFCR ELGVALSISS AASSPTLSER HVRITQQQET VEVLPFNSVV
     FTSWAEVKGS RYRVTPDVKV EGNALVYLAV NQSCLIAGST FEHNFLASRH PIPPLNPSTV
     ASLFMLVKYL MSKRLIVSGH DIGDGGLLPS AIEMALAGCR GLQLSLPAHP NPLELMVSET
     PGALVEVPQV HLSEVLRAAR DYRCVAHPLG TVGPEGQGNN VTILQNETVV FQETLTSLQV
     SWTSFSDEMW NLVTPPLHPL EDMHRKDLGR LEHHLGSLRA MCLGSQLRLF SCPTSPRRVA
     ALVLPGSSAP YALMAALQNT GFEVATVTVE ELKRGQSLSG FSGLITCLRT GCQASYASAR
     GWVLALCNDP TCASTLTEFL NRPDTFSICC GEVGFQLLVA LGVVGRSESS PYTYGPTPPQ
     RWAVNLETNV SKLYDSHWLN IQIPQNTKSV FLRVLRGTVL PSWAQGEYLG VRYEQDALEY
     ILRQRGEITL TYHGNAADET LPARHYPRNP TGNSTVAGLT SSDGRHAALI IDPSLMFHPW
     QWQHVPPDLT PLSMSPWAMA FQSIYLWSVK KINDHH