ASB10_HUMAN
ID ASB10_HUMAN Reviewed; 467 AA.
AC Q8WXI3; A0AVH0; Q6ZUL6;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Ankyrin repeat and SOCS box protein 10;
DE Short=ASB-10;
GN Name=ASB10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Kile B.T., Hilton D.J., Nicola N.A.;
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANTS GLC1F SER-48; GLU-65; MET-67; HIS-72; GLN-94; GLU-97; CYS-183;
RP VAL-197; LEU-207; HIS-272; LEU-295; THR-320; GLN-332; TYR-356; HIS-360 AND
RP GLY-440, VARIANTS GLC1F SER-19; SER-32 AND GLN-39 (ISOFORM 3), VARIANTS
RP VAL-88; TYR-91; VAL-172; TRP-189; GLY-237; CYS-304; MET-329; CYS-372;
RP THR-402 AND CYS-453, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22156576; DOI=10.1093/hmg/ddr572;
RA Pasutto F., Keller K.E., Weisschuh N., Sticht H., Samples J.R., Yang Y.F.,
RA Zenkel M., Schlotzer-Schrehardt U., Mardin C.Y., Frezzotti P., Edmunds B.,
RA Kramer P.L., Gramer E., Reis A., Acott T.S., Wirtz M.K.;
RT "Variants in ASB10 are associated with open-angle glaucoma.";
RL Hum. Mol. Genet. 21:1336-1349(2012).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- INTERACTION:
CC Q8WXI3; P80188: LCN2; NbExp=3; IntAct=EBI-3923154, EBI-11911016;
CC Q8WXI3; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-3923154, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22156576}. Nucleus
CC {ECO:0000269|PubMed:22156576}. Note=In the ciliary body, it is detected
CC in the cytoplasm and perinuclear region of the pigmented ciliary
CC epithelial layer. In the retina, it is detected in the nuclei of
CC retinal ganglion cells.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8WXI3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WXI3-2; Sequence=VSP_023357;
CC Name=3;
CC IsoId=Q8WXI3-3; Sequence=VSP_038997;
CC -!- TISSUE SPECIFICITY: Expressed in the eye. The highest expression is
CC observed in the iris, with moderate levels in the trabecular meshwork
CC (TM), the lamina, and the optic nerve; slightly lower levels in the
CC ciliary body, retina, and choroid; and very low levels in the lens.
CC {ECO:0000269|PubMed:22156576}.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- DISEASE: Glaucoma 1, open angle, F (GLC1F) [MIM:603383]: A form of
CC primary open angle glaucoma (POAG). POAG is characterized by a specific
CC pattern of optic nerve and visual field defects. The angle of the
CC anterior chamber of the eye is open, and usually the intraocular
CC pressure is increased. However, glaucoma can occur at any intraocular
CC pressure. The disease is generally asymptomatic until the late stages,
CC by which time significant and irreversible optic nerve damage has
CC already taken place. {ECO:0000269|PubMed:22156576}. Note=The disease is
CC caused by variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; AF417920; AAL59159.1; -; mRNA.
DR EMBL; AK125565; BAC86204.1; -; mRNA.
DR EMBL; AC010973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126351; AAI26352.1; -; mRNA.
DR CCDS; CCDS47749.2; -. [Q8WXI3-2]
DR CCDS; CCDS47750.2; -. [Q8WXI3-1]
DR CCDS; CCDS5921.2; -. [Q8WXI3-3]
DR RefSeq; NP_001135931.2; NM_001142459.1. [Q8WXI3-1]
DR RefSeq; NP_001135932.2; NM_001142460.1. [Q8WXI3-2]
DR RefSeq; NP_543147.2; NM_080871.3. [Q8WXI3-3]
DR AlphaFoldDB; Q8WXI3; -.
DR SMR; Q8WXI3; -.
DR BioGRID; 126459; 87.
DR IntAct; Q8WXI3; 8.
DR MINT; Q8WXI3; -.
DR STRING; 9606.ENSP00000391137; -.
DR iPTMnet; Q8WXI3; -.
DR PhosphoSitePlus; Q8WXI3; -.
DR BioMuta; ASB10; -.
DR DMDM; 126302522; -.
DR MassIVE; Q8WXI3; -.
DR PaxDb; Q8WXI3; -.
DR PeptideAtlas; Q8WXI3; -.
DR PRIDE; Q8WXI3; -.
DR ProteomicsDB; 75063; -. [Q8WXI3-1]
DR ProteomicsDB; 75064; -. [Q8WXI3-2]
DR ProteomicsDB; 75065; -. [Q8WXI3-3]
DR Antibodypedia; 32988; 141 antibodies from 19 providers.
DR DNASU; 136371; -.
DR Ensembl; ENST00000275838.5; ENSP00000275838.1; ENSG00000146926.11. [Q8WXI3-2]
DR Ensembl; ENST00000377867.7; ENSP00000367098.3; ENSG00000146926.11. [Q8WXI3-3]
DR Ensembl; ENST00000420175.3; ENSP00000391137.2; ENSG00000146926.11. [Q8WXI3-1]
DR GeneID; 136371; -.
DR KEGG; hsa:136371; -.
DR MANE-Select; ENST00000420175.3; ENSP00000391137.2; NM_001142459.2; NP_001135931.2.
DR UCSC; uc003wjl.1; human. [Q8WXI3-1]
DR CTD; 136371; -.
DR DisGeNET; 136371; -.
DR GeneCards; ASB10; -.
DR HGNC; HGNC:17185; ASB10.
DR HPA; ENSG00000146926; Tissue enriched (skeletal).
DR MalaCards; ASB10; -.
DR MIM; 603383; phenotype.
DR MIM; 615054; gene.
DR neXtProt; NX_Q8WXI3; -.
DR OpenTargets; ENSG00000146926; -.
DR Orphanet; 353225; NON RARE IN EUROPE: Primary adult open-angle glaucoma.
DR PharmGKB; PA25028; -.
DR VEuPathDB; HostDB:ENSG00000146926; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000158974; -.
DR HOGENOM; CLU_035721_0_0_1; -.
DR InParanoid; Q8WXI3; -.
DR OMA; LHLCQGA; -.
DR OrthoDB; 540084at2759; -.
DR PhylomeDB; Q8WXI3; -.
DR TreeFam; TF323921; -.
DR PathwayCommons; Q8WXI3; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q8WXI3; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 136371; 11 hits in 1110 CRISPR screens.
DR GenomeRNAi; 136371; -.
DR Pharos; Q8WXI3; Tbio.
DR PRO; PR:Q8WXI3; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8WXI3; protein.
DR Bgee; ENSG00000146926; Expressed in hindlimb stylopod muscle and 46 other tissues.
DR ExpressionAtlas; Q8WXI3; baseline and differential.
DR Genevisible; Q8WXI3; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.20; -; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50225; SOCS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Cytoplasm; Disease variant; Glaucoma;
KW Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..467
FT /note="Ankyrin repeat and SOCS box protein 10"
FT /id="PRO_0000066942"
FT REPEAT 115..144
FT /note="ANK 1"
FT REPEAT 147..176
FT /note="ANK 2"
FT REPEAT 180..209
FT /note="ANK 3"
FT REPEAT 214..243
FT /note="ANK 4"
FT REPEAT 247..289
FT /note="ANK 5"
FT REPEAT 293..322
FT /note="ANK 6"
FT REPEAT 326..361
FT /note="ANK 7"
FT DOMAIN 412..464
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT VAR_SEQ 1..106
FT /note="MLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTAS
FT GPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALR -> M
FT PWGKNSSPHWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLA
FT RLQELFPPHSTADLLLESRAAEPRWSSHQRG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_038997"
FT VAR_SEQ 369..406
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_023357"
FT VARIANT 48
FT /note="T -> S (in GLC1F; uncertain pathological
FT significance; dbSNP:rs151344615)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069867"
FT VARIANT 65
FT /note="G -> E (in GLC1F; uncertain pathological
FT significance; dbSNP:rs104886491)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069868"
FT VARIANT 67
FT /note="V -> M (in GLC1F; uncertain pathological
FT significance; dbSNP:rs151344616)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069869"
FT VARIANT 72
FT /note="R -> H (in GLC1F; uncertain pathological
FT significance; dbSNP:rs104886488)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069870"
FT VARIANT 88
FT /note="D -> V (in dbSNP:rs151344617)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069871"
FT VARIANT 91
FT /note="D -> Y (in dbSNP:rs104886490)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069872"
FT VARIANT 94
FT /note="R -> Q (in GLC1F; uncertain pathological
FT significance; dbSNP:rs147737381)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069873"
FT VARIANT 97
FT /note="D -> E (in GLC1F; uncertain pathological
FT significance; dbSNP:rs151344619)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069874"
FT VARIANT 172
FT /note="A -> V (in dbSNP:rs151344604)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069875"
FT VARIANT 183
FT /note="R -> C (in GLC1F; uncertain pathological
FT significance; dbSNP:rs151344605)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069876"
FT VARIANT 189
FT /note="R -> W (in dbSNP:rs104886473)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069877"
FT VARIANT 197
FT /note="A -> V (in GLC1F; uncertain pathological
FT significance; dbSNP:rs151344607)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069878"
FT VARIANT 207
FT /note="V -> L (in GLC1F; uncertain pathological
FT significance; dbSNP:rs104886474)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069879"
FT VARIANT 237
FT /note="R -> G (in dbSNP:rs61735708)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069880"
FT VARIANT 272
FT /note="R -> H (in GLC1F; uncertain pathological
FT significance; dbSNP:rs140602973)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069881"
FT VARIANT 295
FT /note="Q -> L (in GLC1F; uncertain pathological
FT significance; dbSNP:rs151344609)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069882"
FT VARIANT 304
FT /note="R -> C (in dbSNP:rs61735130)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069883"
FT VARIANT 320
FT /note="A -> T (in GLC1F; uncertain pathological
FT significance; dbSNP:rs151344610)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069884"
FT VARIANT 329
FT /note="T -> M (in dbSNP:rs104886481)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069885"
FT VARIANT 332
FT /note="H -> Q (in GLC1F; uncertain pathological
FT significance; dbSNP:rs104886482)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069886"
FT VARIANT 356
FT /note="H -> Y (in GLC1F; uncertain pathological
FT significance; dbSNP:rs151344611)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069887"
FT VARIANT 360
FT /note="R -> H (in GLC1F; uncertain pathological
FT significance; dbSNP:rs151344612)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069888"
FT VARIANT 372
FT /note="R -> C (in dbSNP:rs62489646)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069889"
FT VARIANT 402
FT /note="P -> T (in dbSNP:rs919533)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069890"
FT VARIANT 440
FT /note="S -> G (in GLC1F; uncertain pathological
FT significance; dbSNP:rs104886487)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_069891"
FT VARIANT 453
FT /note="R -> C (in dbSNP:rs3800791)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_022090"
FT CONFLICT 421
FT /note="Q -> R (in Ref. 2; BAC86204)"
FT /evidence="ECO:0000305"
FT CONFLICT 433
FT /note="L -> P (in Ref. 2; BAC86204)"
FT /evidence="ECO:0000305"
FT VARIANT Q8WXI3-3:19
FT /note="P -> S (in GLC1F; uncertain pathological
FT significance; dbSNP:rs104886462)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_082796"
FT VARIANT Q8WXI3-3:32
FT /note="R -> S (in GLC1F; uncertain pathological
FT significance; dbSNP:rs104886465)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_082797"
FT VARIANT Q8WXI3-3:39
FT /note="R -> Q (in GLC1F; uncertain pathological
FT significance; dbSNP:rs104886467)"
FT /evidence="ECO:0000269|PubMed:22156576"
FT /id="VAR_082798"
SQ SEQUENCE 467 AA; 50894 MW; 7C92C07B154479DE CRC64;
MLMSWSPEEC KGQGEPLDDR HPLCARLVEK PSRGSEEHLK SGPGPIVTRT ASGPALAFWQ
AVLAGDVGCV SRILADSSTG LAPDSVFDTS DPERWRDFRF NIRALRLWSL TYEEELTTPL
HVAASRGHTE VLRLLLRRRA RPDSAPGGRT ALHEACAAGH TACVHVLLVA GADPNIADQD
GKRPLHLCRG PGTLECAELL LRFGARVDGR SEEEEETPLH VAARLGHVEL ADLLLRRGAC
PDARNAEGWT PLLAACDVRC QSITDAEATT ARCLQLCSLL LSAGADADAA DQDKQRPLHL
ACRRGHAAVV ELLLSCGVSA NTMDYGGHTP LHCALQGPAA ALAQSPEHVV RALLNHGAVR
VWPGALPKVL ERWSTCPRTI EVLMNTYSVV QLPEEAVGLV TPETLQKHQR FYSSLFALVR
QPRSLQHLSR CALRSHLEGS LPQALPRLPL PPRLLRYLQL DFEGVLY
