ID   ASB11_BOVIN             Reviewed;         323 AA.
AC   Q3SZE4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 11;
DE            Short=ASB-11;
GN   Name=ASB11;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; BC102916; AAI02917.1; -; mRNA.
DR   RefSeq; NP_001029585.1; NM_001034413.2.
DR   AlphaFoldDB; Q3SZE4; -.
DR   SMR; Q3SZE4; -.
DR   STRING; 9913.ENSBTAP00000038650; -.
DR   PaxDb; Q3SZE4; -.
DR   GeneID; 511852; -.
DR   KEGG; bta:511852; -.
DR   CTD; 140456; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   HOGENOM; CLU_000134_4_1_1; -.
DR   InParanoid; Q3SZE4; -.
DR   OrthoDB; 1546307at2759; -.
DR   TreeFam; TF331945; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..323
FT                   /note="Ankyrin repeat and SOCS box protein 11"
FT                   /id="PRO_0000244389"
FT   REPEAT          64..93
FT                   /note="ANK 1"
FT   REPEAT          97..126
FT                   /note="ANK 2"
FT   REPEAT          130..159
FT                   /note="ANK 3"
FT   REPEAT          162..191
FT                   /note="ANK 4"
FT   REPEAT          195..224
FT                   /note="ANK 5"
FT   REPEAT          227..256
FT                   /note="ANK 6"
FT   DOMAIN          273..323
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   323 AA;  35316 MW;  B2A9D118E27C2012 CRC64;
     MEDGSVSYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR IAEEIFGEIS
     DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS SLHEACLGGH VACAKALLEN
     GAHVNGVTVH GATPLFNACC SGSAACVNVL LEFGAKAQLE VHLASPIHEA VKRGNRECME
     ILLANNVNID QEVPHLGTPL YAACTYQRLD CVKKLLELGA NVNHGQWLDT PLHAAAKQNS
     VEIIHLLIDY GANLKCKNAQ GQSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG
     RNCHKTIHKL YLPDPLEKFL LYQ