ID   ORFB_WDSV               Reviewed;         306 AA.
AC   Q88940;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 41.
DE   RecName: Full=ORF-B protein;
OS   Walleye dermal sarcoma virus (WDSV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Epsilonretrovirus.
OX   NCBI_TaxID=39720;
OH   NCBI_TaxID=283036; Sander vitreus (Walleye) (Perca vitrea).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7636975; DOI=10.1128/jvi.69.9.5320-5331.1995;
RA   Holzschu D.L., Martineau D., Fodor S.K., Vogt V.M., Bowser P.R.,
RA   Casey J.W.;
RT   "Nucleotide sequence and protein analysis of a complex piscine retrovirus,
RT   walleye dermal sarcoma virus.";
RL   J. Virol. 69:5320-5331(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Chappey C.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=17698670; DOI=10.1099/vir.0.82967-0;
RA   Rovnak J., Casey R.N., Brewster C.D., Casey J.W., Quackenbush S.L.;
RT   "Establishment of productively infected walleye dermal sarcoma explant
RT   cells.";
RL   J. Gen. Virol. 88:2583-2589(2007).
RN   [4]
RP   INTERACTION WITH WALLEYE RACK1.
RX   PubMed=18343476; DOI=10.1016/j.virol.2008.01.034;
RA   Daniels C.C., Rovnak J., Quackenbush S.L.;
RT   "Walleye dermal sarcoma virus Orf B functions through receptor for
RT   activated C kinase (RACK1) and protein kinase C.";
RL   Virology 375:550-560(2008).
CC   -!- SUBUNIT: Interacts with host RACK1. {ECO:0000269|PubMed:18343476}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:17698670}.
CC       Host cell membrane {ECO:0000305}; Multi-pass membrane protein
CC       {ECO:0000305}.
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DR   EMBL; L41838; AAA99529.1; -; Genomic_RNA.
DR   EMBL; AF033822; AAC82610.1; -; Genomic_RNA.
DR   PIR; T09397; T09397.
DR   RefSeq; NP_045941.1; NC_001867.1.
DR   GeneID; 1403499; -.
DR   KEGG; vg:1403499; -.
DR   Proteomes; UP000007081; Genome.
DR   Proteomes; UP000008337; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host cell membrane; Host cytoplasm; Host membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..306
FT                   /note="ORF-B protein"
FT                   /id="PRO_0000410608"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   306 AA;  34971 MW;  481E2F2690F78EC3 CRC64;
     MFSDSDSSDE ELSRIITDID ESPQDIQQSL HLRAGVSPEA RVPPGGLTQE EWTIDYFSTY
     HTPLLNPGIP HELTQRCTDY TASILRRASA KMIQWDYVFY LLPRVWIMFP FIAREGLSHL
     THLLTLTTSV LSATSLVFGW DLTVIELCNE MNIQGVYLPE VIEWLAQFSF LFTHVTLIVV
     SDGMMDLLLM FPMDIEEQPL AINIALHALQ TSYTIMTPIL FASPLLRIIS CVLYACGHCP
     SARMLYAYTI MNRYTGESIA EMHTGFRCFR DQMIAYDMEF TNFLRDLTEE ETPVLEITEP
     EPSPTE