ID   ORFC_WDSV               Reviewed;         120 AA.
AC   Q88936;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-DEC-2020, entry version 46.
DE   RecName: Full=Protein ORF-C;
GN   Name=orfC;
OS   Walleye dermal sarcoma virus (WDSV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Epsilonretrovirus.
OX   NCBI_TaxID=39720;
OH   NCBI_TaxID=283036; Sander vitreus (Walleye) (Perca vitrea).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7636975; DOI=10.1128/jvi.69.9.5320-5331.1995;
RA   Holzschu D.L., Martineau D., Fodor S.K., Vogt V.M., Bowser P.R.,
RA   Casey J.W.;
RT   "Nucleotide sequence and protein analysis of a complex piscine retrovirus,
RT   walleye dermal sarcoma virus.";
RL   J. Virol. 69:5320-5331(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NY 2003;
RX   PubMed=17698670; DOI=10.1099/vir.0.82967-0;
RA   Rovnak J., Casey R.N., Brewster C.D., Casey J.W., Quackenbush S.L.;
RT   "Establishment of productively infected walleye dermal sarcoma explant
RT   cells.";
RL   J. Gen. Virol. 88:2583-2589(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Chappey C.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=12560570; DOI=10.1099/vir.0.18570-0;
RA   Nudson W.A., Rovnak J., Buechner M., Quackenbush S.L.;
RT   "Walleye dermal sarcoma virus Orf C is targeted to the mitochondria.";
RL   J. Gen. Virol. 84:375-381(2003).
CC   -!- FUNCTION: Induces alteration of mitochondrial function that results in
CC       apoptosis contributing to tumor regression.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion {ECO:0000269|PubMed:12560570}.
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DR   EMBL; L41838; AAA99525.1; -; Genomic_RNA.
DR   EMBL; AF033822; AAC82606.1; -; Genomic_RNA.
DR   EMBL; EF428979; ABO25841.1; -; Genomic_DNA.
DR   PIR; T09392; T09392.
DR   RefSeq; NP_045936.1; NC_001867.1.
DR   GeneID; 1403501; -.
DR   KEGG; vg:1403501; -.
DR   Proteomes; UP000007081; Genome.
DR   Proteomes; UP000008337; Genome.
DR   Proteomes; UP000156462; Genome.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Apoptosis; Host mitochondrion; Reference proteome.
FT   CHAIN           1..120
FT                   /note="Protein ORF-C"
FT                   /id="PRO_0000412273"
SQ   SEQUENCE   120 AA;  14200 MW;  D29AE89F3259104B CRC64;
     MAWYHQHRWH LDYSIPRQNL QAFLTTITFI DPQFKIQENG LTEGEYKTQI VKQIIPQLCR
     IPNQNSPPPI WVQGPRIKGD PTWLKINAKF ITELIPKQKG TKNISTKTYL SRLFVIWLQN