ORG3_ARATH
ID ORG3_ARATH Reviewed; 258 AA.
AC Q9M1K0;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Transcription factor ORG3;
DE AltName: Full=Basic helix-loop-helix protein 39;
DE Short=AtbHLH39;
DE Short=bHLH 39;
DE AltName: Full=OBP3-responsive gene 3;
DE AltName: Full=Transcription factor EN 9;
DE AltName: Full=bHLH transcription factor bHLH039;
GN Name=ORG3; Synonyms=BHLH39, EN9; OrderedLocusNames=At3g56980;
GN ORFNames=F24I3.60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [6]
RP INDUCTION BY OBP3; JASMONIC ACID AND SALICYLIC ACID.
RX PubMed=12887587; DOI=10.1046/j.1365-313x.2003.01812.x;
RA Kang H.-G., Foley R.C., Onate-Sanchez L., Lin C., Singh K.B.;
RT "Target genes for OBP3, a Dof transcription factor, include novel basic
RT helix-loop-helix domain proteins inducible by salicylic acid.";
RL Plant J. 35:362-372(2003).
RN [7]
RP INDUCTION.
RX PubMed=17516080; DOI=10.1007/s00425-007-0535-x;
RA Wang H.-Y., Klatte M., Jakoby M., Baeumlein H., Weisshaar B., Bauer P.;
RT "Iron deficiency-mediated stress regulation of four subgroup Ib BHLH genes
RT in Arabidopsis thaliana.";
RL Planta 226:897-908(2007).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=18296723; DOI=10.1093/pcp/pcn023;
RA Wenzel C.L., Hester Q., Mattsson J.;
RT "Identification of genes expressed in vascular tissues using NPA-induced
RT vascular overgrowth in Arabidopsis.";
RL Plant Cell Physiol. 49:457-468(2008).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q9M1K0; Q0V7X4: FIT; NbExp=5; IntAct=EBI-1640573, EBI-1640543;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in vascular tissues. Detected in roots.
CC {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:18296723}.
CC -!- INDUCTION: Induced by OBP3, auxin and salicylic acid (SA). Repressed by
CC jasmonic acid (JA). Up regulated by iron deficiency in roots and
CC leaves, as well as by nickel, high zinc or high copper treatments.
CC Repressed by high iron, low copper and low zinc treatments.
CC {ECO:0000269|PubMed:12887587, ECO:0000269|PubMed:17516080}.
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DR EMBL; AF488577; AAM10941.1; -; mRNA.
DR EMBL; AL138655; CAB72168.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79595.1; -; Genomic_DNA.
DR PIR; T47758; T47758.
DR RefSeq; NP_191257.1; NM_115557.3.
DR AlphaFoldDB; Q9M1K0; -.
DR SMR; Q9M1K0; -.
DR BioGRID; 10181; 3.
DR IntAct; Q9M1K0; 2.
DR STRING; 3702.AT3G56980.1; -.
DR PaxDb; Q9M1K0; -.
DR PRIDE; Q9M1K0; -.
DR EnsemblPlants; AT3G56980.1; AT3G56980.1; AT3G56980.
DR GeneID; 824865; -.
DR Gramene; AT3G56980.1; AT3G56980.1; AT3G56980.
DR KEGG; ath:AT3G56980; -.
DR Araport; AT3G56980; -.
DR TAIR; locus:2080615; AT3G56980.
DR eggNOG; ENOG502RXMR; Eukaryota.
DR HOGENOM; CLU_089779_1_1_1; -.
DR InParanoid; Q9M1K0; -.
DR OMA; MMVQISS; -.
DR OrthoDB; 1275266at2759; -.
DR PhylomeDB; Q9M1K0; -.
DR PRO; PR:Q9M1K0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M1K0; baseline and differential.
DR Genevisible; Q9M1K0; AT.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0010106; P:cellular response to iron ion starvation; IEP:TAIR.
DR GO; GO:0055072; P:iron ion homeostasis; IGI:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR015660; MASH1/Ascl1a-like.
DR PANTHER; PTHR13935; PTHR13935; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..258
FT /note="Transcription factor ORG3"
FT /id="PRO_0000358851"
FT DOMAIN 76..128
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 258 AA; 29004 MW; 2AE6CBF05422D3E0 CRC64;
MCALVPPLFP NFGWPSTGEY DSYYLAGDIL NNGGFLDFPV PEETYGAVTA VTQHQNSFGV
SVSSEGNEID NNPVVVKKLN HNASERDRRR KINSLFSSLR SCLPASGQSK KLSIPATVSR
SLKYIPELQE QVKKLIKKKE ELLVQISGQR NTECYVKQPP KAVANYISTV SATRLGDNEV
MVQISSSKIH NFSISNVLSG LEEDRFVLVD MSSSRSQGER LFYTLHLQVE KIENYKLNCE
ELSQRMLYLY EECGNSYI
