ID   ORGA_SALTS              Reviewed;         199 AA.
AC   E1WAB5; P40823; P58653;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Oxygen-regulated invasion protein OrgA;
GN   Name=orgA; OrderedLocusNames=SL1344_2850;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=8063389; DOI=10.1128/iai.62.9.3745-3752.1994;
RA   Jones B.D., Falkow S.;
RT   "Identification and characterization of a Salmonella typhimurium oxygen-
RT   regulated gene required for bacterial internalization.";
RL   Infect. Immun. 62:3745-3752(1994).
RN   [2]
RP   SEQUENCE REVISION, AND CHARACTERIZATION.
RC   STRAIN=SL1344;
RX   PubMed=10816487; DOI=10.1128/iai.68.6.3368-3376.2000;
RA   Klein J.R., Fahlen T.F., Jones B.D.;
RT   "Transcriptional organization and function of invasion genes within
RT   Salmonella enterica serovar Typhimurium pathogenicity island 1, including
RT   the prgH, prgI, prgJ, prgK, orgA, orgB, and orgC genes.";
RL   Infect. Immun. 68:3368-3376(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
CC   -!- FUNCTION: Oxygen-regulated protein required for bacterial
CC       internalization.
CC   -!- CAUTION: Was originally thought to be a longer protein that encodes
CC       what is now known to be OrgA and OrgB. {ECO:0000305|PubMed:8063389}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA72055.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L33855; AAA72055.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; FQ312003; CBW18948.1; -; Genomic_DNA.
DR   RefSeq; WP_001574876.1; NZ_QASL01000017.1.
DR   AlphaFoldDB; E1WAB5; -.
DR   EnsemblBacteria; CBW18948; CBW18948; SL1344_2850.
DR   KEGG; sey:SL1344_2850; -.
DR   PATRIC; fig|216597.6.peg.3171; -.
DR   HOGENOM; CLU_092002_0_0_6; -.
DR   OMA; MACQRHR; -.
DR   BioCyc; SENT216597:SL1344_RS14860-MON; -.
DR   Proteomes; UP000008962; Chromosome.
DR   InterPro; IPR013388; T3SS_OrgA/MxiK.
DR   Pfam; PF09482; OrgA_MxiK; 1.
DR   TIGRFAMs; TIGR02555; OrgA_MxiK; 1.
PE   1: Evidence at protein level;
KW   Virulence.
FT   CHAIN           1..199
FT                   /note="Oxygen-regulated invasion protein OrgA"
FT                   /id="PRO_0000406079"
FT   CONFLICT        18
FT                   /note="Q -> R (in Ref. 1; AAA72055)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        22
FT                   /note="F -> V (in Ref. 1; AAA72055)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   199 AA;  22832 MW;  94368148BF784EE3 CRC64;
     MIRRNRQMNR QPLPIIWQRI IFDPLSYIHP QRLQIAPEMI VRPAARAAAN ELILAAWRLK
     NGEKECIQNS LTQLWLRQWR RLPQVAYLLG CHKLRADLAR QGALLGLPDW AQAFLAMHQG
     TSLSVCNKAP NHRFLLSVGY AQLNALNEFL PESLAQRFPL LFPPFIEEAL KQDAVEMSIL
     LLALQYAQKY PNTVPAFAC