ID   ORM2B_HUMAN             Reviewed;         313 AA.
AC   A0A0X1KG70;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   16-MAR-2016, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=Olfactory receptor 4M2 {ECO:0000305};
GN   Name=OR4M2B {ECO:0000312|HGNC:HGNC:55109};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC135068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A0X1KG70; -.
DR   SMR; A0A0X1KG70; -.
DR   STRING; 9606.ENSP00000329467; -.
DR   BioMuta; ENSG00000182974; -.
DR   Antibodypedia; 22170; 21 antibodies from 7 providers.
DR   Ensembl; ENST00000332663.3; ENSP00000329467.3; ENSG00000182974.3.
DR   MANE-Select; ENST00000332663.3; ENSP00000329467.3; NM_001395296.1; NP_001382225.1.
DR   GeneCards; OR4M2B; -.
DR   HGNC; HGNC:55109; OR4M2B.
DR   neXtProt; NX_A0A0X1KG70; -.
DR   VEuPathDB; HostDB:ENSG00000182974; -.
DR   eggNOG; ENOG502SKDS; Eukaryota.
DR   GeneTree; ENSGT00940000163142; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; A0A0X1KG70; protein.
DR   Bgee; ENSG00000182974; Expressed in ventricular zone and 2 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..313
FT                   /note="Olfactory receptor 4M2"
FT                   /id="PRO_0000451613"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..57
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..97
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..142
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        143..163
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        164..204
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        205..225
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..238
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..270
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        271..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..313
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   DISULFID        97..179
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   313 AA;  35403 MW;  A0D788C8FBB5F569 CRC64;
     METANYTKVT EFVLTGLSQT PEVQLVLFVI FLSFYLFILP GNILIICTIS LDPHLTSPMY
     FLLANLAFLD IWYSSITAPE MLIDFFVERK IISFDECIAQ LFFLHFAGAS EMFLLTVMAF
     DLYTAICRPL HYATIMNQRL CCILVALSWR GGFIHSIIQV ALIVRLPFCG PNELDSYFCD
     ITQVVRIACA NTFPEELVMI CSSGLISVVC LIALLMSYAF LLALLKKLSG SGENTNRAVS
     TCYSHITIVV LMFGPSIYIY ARPFDSFSLD KVVSVFNTLI FPLHNPIIYT LRNKEVKAAM
     RKLVTKYILC KEK