ID   ASB11_PONAB             Reviewed;         323 AA.
AC   Q5RFS1;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Ankyrin repeat and SOCS box protein 11;
DE            Short=ASB-11;
GN   Name=ASB11;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC       (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000305}.
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DR   EMBL; CR857081; CAH89386.1; -; mRNA.
DR   RefSeq; NP_001124584.1; NM_001131112.1.
DR   AlphaFoldDB; Q5RFS1; -.
DR   SMR; Q5RFS1; -.
DR   STRING; 9601.ENSPPYP00000022531; -.
DR   Ensembl; ENSPPYT00000023489; ENSPPYP00000022531; ENSPPYG00000020141.
DR   GeneID; 100171419; -.
DR   KEGG; pon:100171419; -.
DR   CTD; 140456; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000160592; -.
DR   HOGENOM; CLU_000134_4_1_1; -.
DR   InParanoid; Q5RFS1; -.
DR   OMA; RPGLWKE; -.
DR   OrthoDB; 1546307at2759; -.
DR   TreeFam; TF331945; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001595; Chromosome X.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03728; SOCS_ASB_9_11; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037333; ASB9/11_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 5.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..323
FT                   /note="Ankyrin repeat and SOCS box protein 11"
FT                   /id="PRO_0000066946"
FT   REPEAT          64..93
FT                   /note="ANK 1"
FT   REPEAT          97..126
FT                   /note="ANK 2"
FT   REPEAT          130..159
FT                   /note="ANK 3"
FT   REPEAT          162..191
FT                   /note="ANK 4"
FT   REPEAT          195..224
FT                   /note="ANK 5"
FT   REPEAT          227..256
FT                   /note="ANK 6"
FT   DOMAIN          274..323
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ   SEQUENCE   323 AA;  35348 MW;  7BD85C75FCBAF322 CRC64;
     MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR IAEEIYGGIS
     DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS SLHEACLGGH VACAKALLEN
     GAHVNGVTVH GATPLFNACC SGSAACVNVL LEFGAKAQFE VHLASPIHEA VKRGHRECME
     ILLANNVNID HEVPQLGTPL YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN
     VEVIHLLTDY GANLKRRNAQ GKSALDLAAP KSSVEQALLL CEGPPALSQL CRLCVRKCLG
     RACHQAIHKL HLPEPLERFL LYQ