ID   ORML1_BOVIN             Reviewed;         153 AA.
AC   Q29RQ9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=ORM1-like protein 1;
GN   Name=ORMDL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
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DR   EMBL; BC114067; AAI14068.1; -; mRNA.
DR   RefSeq; NP_001070601.1; NM_001077133.1.
DR   RefSeq; XP_005202286.1; XM_005202229.2.
DR   AlphaFoldDB; Q29RQ9; -.
DR   SMR; Q29RQ9; -.
DR   STRING; 9913.ENSBTAP00000016673; -.
DR   PaxDb; Q29RQ9; -.
DR   PRIDE; Q29RQ9; -.
DR   Ensembl; ENSBTAT00000016673; ENSBTAP00000016673; ENSBTAG00000012561.
DR   GeneID; 768077; -.
DR   KEGG; bta:768077; -.
DR   CTD; 94101; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012561; -.
DR   VGNC; VGNC:32452; ORMDL1.
DR   eggNOG; KOG3319; Eukaryota.
DR   GeneTree; ENSGT00950000183178; -.
DR   HOGENOM; CLU_072117_3_0_1; -.
DR   InParanoid; Q29RQ9; -.
DR   OMA; DPTHFII; -.
DR   OrthoDB; 1405600at2759; -.
DR   TreeFam; TF323369; -.
DR   Reactome; R-BTA-1660661; Sphingolipid de novo biosynthesis.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000012561; Expressed in caput epididymis and 106 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; IBA:GO_Central.
DR   GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:0061744; P:motor behavior; IEA:Ensembl.
DR   GO; GO:0042552; P:myelination; IEA:Ensembl.
DR   GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006686; P:sphingomyelin biosynthetic process; IEA:Ensembl.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029884; ORML1.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF12; PTHR12665:SF12; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="ORM1-like protein 1"
FT                   /id="PRO_0000263064"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17361 MW;  1262EC884340827D CRC64;
     MNVGVAHSEV NPNTRVMNSR GMWLTYALGV GLLHIVLLSI PFFSVPVAWT LTNVIHNLGM
     YVFLHAVKGT PFETPDQGKA RLLTHWEQLD YGVQFTSSRK FFTISPIILY FLASFYTKYD
     TTHFILNTAS LLSVLIPKMP QLHGVRIFGI NKY