ID   ORML1_PONAB             Reviewed;         153 AA.
AC   Q5R8X5;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=ORM1-like protein 1;
GN   Name=ORMDL1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
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DR   EMBL; CR859623; CAH91785.1; -; mRNA.
DR   RefSeq; NP_001127461.1; NM_001133989.2.
DR   RefSeq; XP_009236172.1; XM_009237897.1.
DR   RefSeq; XP_009236173.1; XM_009237898.1.
DR   RefSeq; XP_009236174.1; XM_009237899.1.
DR   RefSeq; XP_009236176.1; XM_009237901.1.
DR   RefSeq; XP_009236177.1; XM_009237902.1.
DR   RefSeq; XP_009236178.1; XM_009237903.1.
DR   RefSeq; XP_009236179.1; XM_009237904.1.
DR   AlphaFoldDB; Q5R8X5; -.
DR   SMR; Q5R8X5; -.
DR   STRING; 9601.ENSPPYP00000014542; -.
DR   Ensembl; ENSPPYT00000015131; ENSPPYP00000014542; ENSPPYG00000013017.
DR   GeneID; 100174534; -.
DR   KEGG; pon:100174534; -.
DR   CTD; 94101; -.
DR   eggNOG; KOG3319; Eukaryota.
DR   GeneTree; ENSGT00950000183178; -.
DR   HOGENOM; CLU_072117_3_0_1; -.
DR   InParanoid; Q5R8X5; -.
DR   OrthoDB; 1405600at2759; -.
DR   Proteomes; UP000001595; Chromosome 2B.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:0061744; P:motor behavior; IEA:Ensembl.
DR   GO; GO:0042552; P:myelination; IEA:Ensembl.
DR   GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006686; P:sphingomyelin biosynthetic process; IEA:Ensembl.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029884; ORML1.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF12; PTHR12665:SF12; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="ORM1-like protein 1"
FT                   /id="PRO_0000215632"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17371 MW;  CEFF155BE8C33A46 CRC64;
     MNVGVAHSEV NPNTRVMNSR GMWLTYALGV GLLHIVLLSI PFFSVPVAWT LTNIIHNLGM
     YVFLHAVKGT PFETPDQGKA RLLTHWEQLD YGVQFTSSRK FFTISPIILY FLASFYTKYD
     PTHFILNTAS LLSVLIPKMP QLHGVRIFGI NKY