ID   ORML1_XENLA             Reviewed;         153 AA.
AC   Q5XH57;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=ORM1-like protein 1;
GN   Name=ormdl1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
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DR   EMBL; BC084216; AAH84216.1; -; mRNA.
DR   RefSeq; NP_001088231.1; NM_001094762.1.
DR   AlphaFoldDB; Q5XH57; -.
DR   SMR; Q5XH57; -.
DR   MaxQB; Q5XH57; -.
DR   DNASU; 495061; -.
DR   GeneID; 495061; -.
DR   KEGG; xla:495061; -.
DR   CTD; 495061; -.
DR   Xenbase; XB-GENE-6254530; ormdl1.S.
DR   OMA; DPTHFII; -.
DR   OrthoDB; 1405600at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 495061; Expressed in brain and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:0090155; P:negative regulation of sphingolipid biosynthetic process; IEA:InterPro.
DR   GO; GO:2000303; P:regulation of ceramide biosynthetic process; IEA:UniProt.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029884; ORML1.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF12; PTHR12665:SF12; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="ORM1-like protein 1"
FT                   /id="PRO_0000215634"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17357 MW;  14CE3641A788C759 CRC64;
     MNVGVAHSEV NPNTRVMNSR GMWLTYALGV GMLHIVLLSI PFFSVPVAWT LTNVIHNLGM
     YVFLHAVKGT PFETPDQGKA RLLTHWEQLD YGVQFTSSRK FLTISPIILY FLASFYTKYD
     PTHFFINTAS LLSVLIPKLP QLHGVRIFGI NKY