ID   ORML2_BOVIN             Reviewed;         153 AA.
AC   Q5E972; Q32KP3;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=ORM1-like protein 2;
GN   Name=ORMDL2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
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DR   EMBL; BT021048; AAX09065.1; -; mRNA.
DR   EMBL; BC109992; AAI09993.1; -; mRNA.
DR   RefSeq; NP_001014931.1; NM_001014931.1.
DR   RefSeq; XP_005206638.1; XM_005206581.2.
DR   RefSeq; XP_005206639.1; XM_005206582.3.
DR   AlphaFoldDB; Q5E972; -.
DR   SMR; Q5E972; -.
DR   STRING; 9913.ENSBTAP00000027540; -.
DR   PaxDb; Q5E972; -.
DR   PRIDE; Q5E972; -.
DR   Ensembl; ENSBTAT00000027540; ENSBTAP00000027540; ENSBTAG00000020663.
DR   GeneID; 515878; -.
DR   KEGG; bta:515878; -.
DR   CTD; 29095; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020663; -.
DR   VGNC; VGNC:32453; ORMDL2.
DR   eggNOG; KOG3319; Eukaryota.
DR   GeneTree; ENSGT00950000183178; -.
DR   HOGENOM; CLU_072117_3_0_1; -.
DR   InParanoid; Q5E972; -.
DR   OMA; STHYTHF; -.
DR   OrthoDB; 1405600at2759; -.
DR   TreeFam; TF323369; -.
DR   Reactome; R-BTA-1660661; Sphingolipid de novo biosynthesis.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000020663; Expressed in oviduct epithelium and 102 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; IBA:GO_Central.
DR   GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029886; ORML2.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF13; PTHR12665:SF13; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="ORM1-like protein 2"
FT                   /id="PRO_0000215635"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17404 MW;  3387D6A2CA860AEE CRC64;
     MNVGVAHSEV NPNTRVMNSR GIWLAYIILV GLLHVVLLSI PFFSIPVVWT LTNVIHNLVM
     YVFLHTVKGT PFETPDQGKA RLLTHWEQMD YGLQFTSSRK FLSISPIVLY LLASFYTKYD
     AAHFLINTAS LLSVLLPKLP QFHGVRLFGI NKY