ID   ORML2_CHICK             Reviewed;         153 AA.
AC   Q5ZIU0;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=ORM1-like protein 2;
GN   Name=ORMDL2; ORFNames=RCJMB04_23j5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ720694; CAG32353.1; -; mRNA.
DR   RefSeq; NP_001026496.1; NM_001031325.1.
DR   AlphaFoldDB; Q5ZIU0; -.
DR   SMR; Q5ZIU0; -.
DR   PaxDb; Q5ZIU0; -.
DR   GeneID; 425059; -.
DR   KEGG; gga:425059; -.
DR   CTD; 29095; -.
DR   VEuPathDB; HostDB:geneid_425059; -.
DR   InParanoid; Q5ZIU0; -.
DR   OrthoDB; 1405600at2759; -.
DR   PhylomeDB; Q5ZIU0; -.
DR   PRO; PR:Q5ZIU0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; IBA:GO_Central.
DR   GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029886; ORML2.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF13; PTHR12665:SF13; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="ORM1-like protein 2"
FT                   /id="PRO_0000215638"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17360 MW;  331805C2B1406197 CRC64;
     MNVGVAHSEV NPNTRVMSSR GIWLAYVISV AALHVILLSI PFFSIPVVWT LTNVIHNLVM
     YLLLHTVKGT PFETPDQGKD RLLTHWEQID YGMQCTSSRK FLSISPVVLY LLTSFYIKYD
     PAHFMINTAS LLSVLLPKLP QFHGVRVFGI NKY