ORML2_MOUSE
ID ORML2_MOUSE Reviewed; 153 AA.
AC Q9CQZ0; Q8CF72; Q9CSJ7; Q9CVL6;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=ORM1-like protein 2;
GN Name=Ormdl2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Negative regulator of sphingolipid synthesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CQZ0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CQZ0-2; Sequence=VSP_016051;
CC -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
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DR EMBL; AK002583; BAB22207.1; -; mRNA.
DR EMBL; AK002824; BAC25010.1; -; mRNA.
DR EMBL; AK007548; BAB25101.1; -; mRNA.
DR EMBL; AK012681; BAB28407.1; -; mRNA.
DR EMBL; AK013455; BAB28864.1; -; mRNA.
DR EMBL; BC002146; AAH02146.1; -; mRNA.
DR CCDS; CCDS24295.1; -. [Q9CQZ0-1]
DR RefSeq; NP_077142.1; NM_024180.5. [Q9CQZ0-1]
DR RefSeq; XP_006514022.1; XM_006513959.2.
DR AlphaFoldDB; Q9CQZ0; -.
DR SMR; Q9CQZ0; -.
DR IntAct; Q9CQZ0; 7.
DR STRING; 10090.ENSMUSP00000026409; -.
DR iPTMnet; Q9CQZ0; -.
DR PhosphoSitePlus; Q9CQZ0; -.
DR EPD; Q9CQZ0; -.
DR jPOST; Q9CQZ0; -.
DR MaxQB; Q9CQZ0; -.
DR PaxDb; Q9CQZ0; -.
DR PeptideAtlas; Q9CQZ0; -.
DR PRIDE; Q9CQZ0; -.
DR ProteomicsDB; 294347; -. [Q9CQZ0-1]
DR ProteomicsDB; 294348; -. [Q9CQZ0-2]
DR TopDownProteomics; Q9CQZ0-1; -. [Q9CQZ0-1]
DR Antibodypedia; 53765; 86 antibodies from 17 providers.
DR DNASU; 66844; -.
DR Ensembl; ENSMUST00000026409; ENSMUSP00000026409; ENSMUSG00000025353. [Q9CQZ0-1]
DR Ensembl; ENSMUST00000217685; ENSMUSP00000151644; ENSMUSG00000025353. [Q9CQZ0-2]
DR Ensembl; ENSMUST00000219215; ENSMUSP00000151335; ENSMUSG00000025353. [Q9CQZ0-1]
DR Ensembl; ENSMUST00000219524; ENSMUSP00000151697; ENSMUSG00000025353. [Q9CQZ0-1]
DR GeneID; 66844; -.
DR KEGG; mmu:66844; -.
DR UCSC; uc007hoo.2; mouse. [Q9CQZ0-1]
DR CTD; 29095; -.
DR MGI; MGI:1914094; Ormdl2.
DR VEuPathDB; HostDB:ENSMUSG00000025353; -.
DR eggNOG; KOG3319; Eukaryota.
DR GeneTree; ENSGT00950000183178; -.
DR HOGENOM; CLU_072117_3_0_1; -.
DR InParanoid; Q9CQZ0; -.
DR OMA; STHYTHF; -.
DR OrthoDB; 1405600at2759; -.
DR PhylomeDB; Q9CQZ0; -.
DR TreeFam; TF323369; -.
DR Reactome; R-MMU-1660661; Sphingolipid de novo biosynthesis.
DR BioGRID-ORCS; 66844; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Ormdl2; mouse.
DR PRO; PR:Q9CQZ0; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9CQZ0; protein.
DR Bgee; ENSMUSG00000025353; Expressed in right kidney and 232 other tissues.
DR Genevisible; Q9CQZ0; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0035339; C:SPOTS complex; IBA:GO_Central.
DR GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; ISO:MGI.
DR InterPro; IPR007203; ORMDL.
DR InterPro; IPR029886; ORML2.
DR PANTHER; PTHR12665; PTHR12665; 1.
DR PANTHER; PTHR12665:SF13; PTHR12665:SF13; 1.
DR Pfam; PF04061; ORMDL; 1.
DR PIRSF; PIRSF018147; ORMDL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..153
FT /note="ORM1-like protein 2"
FT /id="PRO_0000215637"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..59
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_016051"
FT CONFLICT 37
FT /note="L -> P (in Ref. 1; BAB28407)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 153 AA; 17390 MW; 3ECCA8B2DB88ED66 CRC64;
MNVGVAHSEV NPNTRVMNSR GIWLAYIILV GLLHVVLLSI PFFSIPVVWT LTNVIHNLAM
YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGLQFTSSRK FLSISPIVLY LLASFYTKYD
AAHFLINTAS LLSVLLPKLP QFHGVRLFGI NKY
