ID   ORML3_BOVIN             Reviewed;         153 AA.
AC   Q0VD15;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=ORM1-like protein 3;
GN   Name=ORMDL3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis. May indirectly
CC       regulate endoplasmic reticulum-mediated Ca(+2) signaling (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SPTLC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
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DR   EMBL; BC119888; AAI19889.1; -; mRNA.
DR   RefSeq; NP_001069835.1; NM_001076367.1.
DR   RefSeq; XP_005220811.1; XM_005220754.3.
DR   RefSeq; XP_005220812.1; XM_005220755.3.
DR   AlphaFoldDB; Q0VD15; -.
DR   SMR; Q0VD15; -.
DR   STRING; 9913.ENSBTAP00000018402; -.
DR   PaxDb; Q0VD15; -.
DR   PRIDE; Q0VD15; -.
DR   Ensembl; ENSBTAT00000018402; ENSBTAP00000018402; ENSBTAG00000013855.
DR   GeneID; 615368; -.
DR   KEGG; bta:615368; -.
DR   CTD; 94103; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013855; -.
DR   VGNC; VGNC:32454; ORMDL3.
DR   eggNOG; KOG3319; Eukaryota.
DR   GeneTree; ENSGT00950000183178; -.
DR   HOGENOM; CLU_072117_3_0_1; -.
DR   InParanoid; Q0VD15; -.
DR   OMA; YDQVHFI; -.
DR   OrthoDB; 1405600at2759; -.
DR   TreeFam; TF323369; -.
DR   Reactome; R-BTA-1660661; Sphingolipid de novo biosynthesis.
DR   Reactome; R-BTA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000013855; Expressed in subcutaneous adipose tissue and 107 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; ISS:UniProtKB.
DR   GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:0061744; P:motor behavior; IEA:Ensembl.
DR   GO; GO:0042552; P:myelination; IEA:Ensembl.
DR   GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
DR   GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; IBA:GO_Central.
DR   GO; GO:1904221; P:negative regulation of serine C-palmitoyltransferase activity; IEA:Ensembl.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
DR   GO; GO:0006940; P:regulation of smooth muscle contraction; IEA:Ensembl.
DR   GO; GO:0006686; P:sphingomyelin biosynthetic process; IEA:Ensembl.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029883; ORML3.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF11; PTHR12665:SF11; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="ORM1-like protein 3"
FT                   /id="PRO_0000394252"
FT   TOPO_DOM        1..21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..94
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17495 MW;  61F483CA5DF20B32 CRC64;
     MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT LTNLIHNMGM
     YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK FLTITPIVLY FLTSFYTKYD
     QIHFILNTVS LMSVLIPKLP QLHGVRIFGI NKY