ID   ORML3_DANRE             Reviewed;         153 AA.
AC   Q5XJR6;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=ORM1-like protein 3;
GN   Name=ormdl3; ORFNames=zgc:101654;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
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DR   EMBL; BC083232; AAH83232.1; -; mRNA.
DR   RefSeq; NP_001006087.1; NM_001006087.1.
DR   AlphaFoldDB; Q5XJR6; -.
DR   SMR; Q5XJR6; -.
DR   STRING; 7955.ENSDARP00000032009; -.
DR   PaxDb; Q5XJR6; -.
DR   Ensembl; ENSDART00000038310; ENSDARP00000032009; ENSDARG00000025555.
DR   Ensembl; ENSDART00000184796; ENSDARP00000145108; ENSDARG00000110450.
DR   GeneID; 450067; -.
DR   KEGG; dre:450067; -.
DR   CTD; 94103; -.
DR   ZFIN; ZDB-GENE-041010-190; ormdl3.
DR   eggNOG; KOG3319; Eukaryota.
DR   GeneTree; ENSGT00950000183178; -.
DR   HOGENOM; CLU_072117_3_0_1; -.
DR   InParanoid; Q5XJR6; -.
DR   OMA; YDQVHFI; -.
DR   OrthoDB; 1405600at2759; -.
DR   PhylomeDB; Q5XJR6; -.
DR   TreeFam; TF323369; -.
DR   Reactome; R-DRE-1660661; Sphingolipid de novo biosynthesis.
DR   Reactome; R-DRE-6798695; Neutrophil degranulation.
DR   PRO; PR:Q5XJR6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000025555; Expressed in liver and 21 other tissues.
DR   ExpressionAtlas; Q5XJR6; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; ISS:UniProtKB.
DR   GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029883; ORML3.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF11; PTHR12665:SF11; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="ORM1-like protein 3"
FT                   /id="PRO_0000215643"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17613 MW;  DDBFBC6E022656B0 CRC64;
     MNVGTAHSEV NPNTRVMNSR GIWLSYVLGI GLLHIILLSI PFVSVPVVWT LTNLIHNMCM
     YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK FLTITPIILY FLTSFYTKYD
     RVHFVINTIS LLTVLIPKLP QFHGVRLFGI NKY