ORML3_MOUSE
ID ORML3_MOUSE Reviewed; 153 AA.
AC Q9CPZ6; A2A4X7; Q8BN65; Q8R0U5;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=ORM1-like protein 3;
GN Name=Ormdl3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Eye, Thymus, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Negative regulator of sphingolipid synthesis. May indirectly
CC regulate endoplasmic reticulum-mediated Ca(+2) signaling (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SPTLC1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK009621; BAB26397.1; -; mRNA.
DR EMBL; AK012718; BAB28432.1; -; mRNA.
DR EMBL; AK154085; BAE32363.1; -; mRNA.
DR EMBL; AK087497; BAC39898.1; -; mRNA.
DR EMBL; AL591125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466556; EDL16151.1; -; Genomic_DNA.
DR EMBL; BC026412; AAH26412.1; -; mRNA.
DR EMBL; BC046594; AAH46594.1; -; mRNA.
DR CCDS; CCDS25355.1; -.
DR RefSeq; NP_079937.1; NM_025661.4.
DR AlphaFoldDB; Q9CPZ6; -.
DR SMR; Q9CPZ6; -.
DR BioGRID; 211595; 2.
DR IntAct; Q9CPZ6; 1.
DR STRING; 10090.ENSMUSP00000053056; -.
DR iPTMnet; Q9CPZ6; -.
DR PhosphoSitePlus; Q9CPZ6; -.
DR EPD; Q9CPZ6; -.
DR jPOST; Q9CPZ6; -.
DR MaxQB; Q9CPZ6; -.
DR PaxDb; Q9CPZ6; -.
DR PeptideAtlas; Q9CPZ6; -.
DR PRIDE; Q9CPZ6; -.
DR ProteomicsDB; 295475; -.
DR TopDownProteomics; Q9CPZ6; -.
DR Antibodypedia; 54876; 117 antibodies from 22 providers.
DR DNASU; 66612; -.
DR Ensembl; ENSMUST00000052919; ENSMUSP00000053056; ENSMUSG00000038150.
DR GeneID; 66612; -.
DR KEGG; mmu:66612; -.
DR UCSC; uc007lgr.1; mouse.
DR CTD; 94103; -.
DR MGI; MGI:1913862; Ormdl3.
DR VEuPathDB; HostDB:ENSMUSG00000038150; -.
DR eggNOG; KOG3319; Eukaryota.
DR GeneTree; ENSGT00950000183178; -.
DR HOGENOM; CLU_072117_3_0_1; -.
DR InParanoid; Q9CPZ6; -.
DR OMA; YDQVHFI; -.
DR OrthoDB; 1405600at2759; -.
DR PhylomeDB; Q9CPZ6; -.
DR TreeFam; TF323369; -.
DR Reactome; R-MMU-1660661; Sphingolipid de novo biosynthesis.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 66612; 6 hits in 73 CRISPR screens.
DR ChiTaRS; Ormdl3; mouse.
DR PRO; PR:Q9CPZ6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9CPZ6; protein.
DR Bgee; ENSMUSG00000038150; Expressed in olfactory epithelium and 249 other tissues.
DR Genevisible; Q9CPZ6; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0035339; C:SPOTS complex; ISS:UniProtKB.
DR GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR GO; GO:0061744; P:motor behavior; IGI:MGI.
DR GO; GO:0042552; P:myelination; IGI:MGI.
DR GO; GO:0002903; P:negative regulation of B cell apoptotic process; IMP:MGI.
DR GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; IDA:MGI.
DR GO; GO:1904221; P:negative regulation of serine C-palmitoyltransferase activity; IMP:MGI.
DR GO; GO:0010508; P:positive regulation of autophagy; IMP:MGI.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; ISO:MGI.
DR GO; GO:2000303; P:regulation of ceramide biosynthetic process; IMP:MGI.
DR GO; GO:0006940; P:regulation of smooth muscle contraction; IMP:MGI.
DR GO; GO:0090153; P:regulation of sphingolipid biosynthetic process; IMP:MGI.
DR GO; GO:0006686; P:sphingomyelin biosynthetic process; IMP:MGI.
DR InterPro; IPR007203; ORMDL.
DR InterPro; IPR029883; ORML3.
DR PANTHER; PTHR12665; PTHR12665; 1.
DR PANTHER; PTHR12665:SF11; PTHR12665:SF11; 1.
DR Pfam; PF04061; ORMDL; 1.
DR PIRSF; PIRSF018147; ORMDL; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..153
FT /note="ORM1-like protein 3"
FT /id="PRO_0000215640"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 58
FT /note="L -> Q (in Ref. 1; BAC39898)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 153 AA; 17477 MW; E37EB8D0E958EB2D CRC64;
MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT LTNLIHNLGM
YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK FLTITPIVLY FLTSFYTKYD
QVHFILNTVS LMTVLIPKLP QLHGVRIFGI NKY
