ID   ORML3_PONAB             Reviewed;         153 AA.
AC   Q5R570;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=ORM1-like protein 3;
GN   Name=ORMDL3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis. May indirectly
CC       regulate endoplasmic reticulum-mediated Ca(+2) signaling (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SPTLC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
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DR   EMBL; CR860995; CAH93096.1; -; mRNA.
DR   RefSeq; NP_001126832.1; NM_001133360.1.
DR   RefSeq; XP_009250108.1; XM_009251833.1.
DR   AlphaFoldDB; Q5R570; -.
DR   SMR; Q5R570; -.
DR   STRING; 9601.ENSPPYP00000023941; -.
DR   Ensembl; ENSPPYT00000009902; ENSPPYP00000009521; ENSPPYG00000008473.
DR   GeneID; 100173839; -.
DR   KEGG; pon:100173839; -.
DR   CTD; 94103; -.
DR   eggNOG; KOG3319; Eukaryota.
DR   GeneTree; ENSGT00950000183178; -.
DR   HOGENOM; CLU_072117_3_0_1; -.
DR   InParanoid; Q5R570; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; ISS:UniProtKB.
DR   GO; GO:0090156; P:cellular sphingolipid homeostasis; IEA:InterPro.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:2000303; P:regulation of ceramide biosynthetic process; IEA:UniProt.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029883; ORML3.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF11; PTHR12665:SF11; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="ORM1-like protein 3"
FT                   /id="PRO_0000215641"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   153 AA;  17481 MW;  61F483CA4303E432 CRC64;
     MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT LTNLIHNMGM
     YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK FLTITPIVLY FLTSFYTKYD
     QIHFVLNTVS LMSVLIPKLP QLHGVRIFGI NKY